Mendelian randomization study of obesity and cerebrovascular disease,Annals of Neurology

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Mendelian randomization study of obesity and cerebrovascular disease
Annals of Neurology ( IF 11.2 ) Pub Date : 2020-04-01 , DOI: 10.1002/ana.25686
Sandro Marini _{1,

2} , Jordi Merino _{1,

3,

4,

5} , Bailey E Montgomery ₁ , Rainer Malik ₆ , Catherine L Sudlow ₇ , Martin Dichgans _{6,

8,

9} , Jose C Florez _{1,

3,

4,

10} , Jonathan Rosand _{1,

10,

11,

12} , Dipender Gill ₁₃ , Christopher D Anderson _{1,

10,

11,

12} ,

Affiliation

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.
Department of Neurology, Boston University Medical Center, Boston, MA.
Diabetes Unit, Massachusetts General Hospital, Boston, MA.
Department of Medicine, Harvard Medical School, Boston, MA.
Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, Sant Joan University Hospital, Rovira i Virgili University, Pere Virgili Health Research Institute, Spanish Biomedical Research Network in Diabetes and Associated Metabolic Disorders, Reus, Spain.
Institute for Stroke and Dementia Research, University Hospital of Ludwig Maximilian University, Munich, Germany.
Center for Medical Informatics, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom.
Munich Cluster for Systems Neurology, Munich, Germany.
German Center for Neurodegenerative Diseases, Munich, Germany.
Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA.
Department of Neurology, Massachusetts General Hospital, Boston, MA.
Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA.
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.

To systematically investigate causal relationships between obesity and cerebrovascular disease and the extent to which hypertension and hyperglycemia mediate the effect of obesity on cerebrovascular disease.

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