Antibacterial photodynamic therapy (APDT) is an encouraging therapy modality for bacterial infection. In this work, trithiophene aldehyde (3T‐CHO) as a new photosensitizers was isolated from Herba Ecliptae, and tryptophan (Trp) modified 3T‐CHO improve water solubility and reduced phototoxicity. The photosensitizer‐loaded vesicles were incorporated into a gel scaffold to obtain a wound dressing with detection and antibacterial function. Detection of the presence of pathogenic bacteria, such as Pseudomonas aeruginosa, based on the fluorescence signals was highly efficient and sensitive. The cytotoxin produced by the pathogenic bacteria to induce vesicle lysis, thereby the photosensitive antibacterial agent was released from the vesicle to realize the simultaneous intelligent detection and treatment of pathogenic bacteria. Compared with traditional dressings coated with antibiotics, the synthesized dressing avoids the drawback of pathogenic bacteria developing drug resistance. The proposed microbiologically responsive wound dressing could be used as a general methodology for the design and fabrication of bacterium‐responsive functional biomaterials.

中文翻译：

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智能光敏抗菌伤口敷料的开发：细菌感染的同步检测和治疗，以促进伤口愈合

抗菌光动力疗法（APDT）是一种令人鼓舞的细菌感染疗法。在这项工作中，从草科植物中分离了作为新光敏剂的三噻吩醛（3T-CHO），色氨酸（Trp）修饰的3T​​-CHO改善了水溶性并降低了光毒性。将装有光敏剂的囊泡掺入凝胶支架中，以获得具有检测和抗菌功能的伤口敷料。检测病原细菌的存在，例如铜绿假单胞菌，基于荧光信号是高效且敏感的。病原菌产生的细胞毒素诱导囊泡溶解，从而从囊泡中释放出光敏抗菌剂，实现了病原菌的同时智能检测与治疗。与传统的敷有抗生素的敷料相比，该合成敷料避免了病原菌产生耐药性的缺点。拟议的微生物反应性伤口敷料可以用作设计和制造细菌反应性功能生物材料的通用方法。