Functional metal-organic frameworks (MOFs) constructed via a pre-installation strategy of introducing mixed organic ligands have attracted considerable interest in various fields. In the present study, boronic acid decorated magnetic Zr-MOFs were successfully synthesized by introducing 3-carboxyphenylboronic acid ligands as fragments. The prepared material was used as an adsorbent for the enrichment of cis-diol-containing nucleosides. The adsorbent has excellent performance with regard to the enrichment and separation of the nucleosides. This may be attributed to its abundant boronic acid functional groups, and the convenience of magnetic separation it provides. The obtained material was chemically stable over a large pH range. The degree of linearity of the nucleosides was excellent (0.02-10 μg mL-1), and the detection and quantification limits were low (0.006-0.016 μg mL-1 and 0.02-0.05 μg mL-1, respectively). Furthermore, it was possible to attain adsorption equilibrium within 10 min. The high efficiency of this method makes it suitable for the successful extraction of nucleosides from human urine samples, with satisfactory recoveries of 88-146%, and 1.7-9.4% precision. We believe that the fabricated functional magnetic MOFs have great potential for the analysis of other cis-diol-containing target, and the pre-installation strategy could be adapted for the wider application of MOFs.

中文翻译：

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通过混合配体策略修饰硼酸修饰的金属有机框架，选择性富集含有核苷的顺式二醇

通过引入混合有机配体的预安装策略构建的功能性金属有机框架（MOF）在各个领域引起了极大的兴趣。在本研究中，通过引入 3-羧基苯基硼酸配体作为片段，成功合成了硼酸装饰的磁性 Zr-MOFs。制备的材料用作富集含顺式二醇核苷的吸附剂。该吸附剂在核苷的富集和分离方面具有优异的性能。这可能归因于其丰富的硼酸官能团，以及它提供的磁分离的便利性。所得材料在较大的 pH 值范围内具有化学稳定性。核苷的线性度非常好（0.02-10 μg mL-1），检测限和定量限较低（分别为 0.006-0.016 μg mL-1 和 0.02-0.05 μg mL-1）。此外，可以在 10 分钟内达到吸附平衡。该方法的高效性使其适用于从人尿样品中成功提取核苷，回收率为 88-146%，精度为 1.7-9.4%。我们相信所制备的功能性磁性 MOFs 在分析其他含顺式二醇的目标方面具有很大的潜力，并且预安装策略可以适应 MOFs 的更广泛应用。该方法的高效性使其适用于从人尿样品中成功提取核苷，回收率为 88-146%，精度为 1.7-9.4%。我们相信所制备的功能性磁性 MOFs 在分析其他含顺式二醇的目标方面具有很大的潜力，并且预安装策略可以适应 MOFs 的更广泛应用。该方法的高效性使其适用于从人尿样品中成功提取核苷，回收率为 88-146%，精度为 1.7-9.4%。我们相信所制备的功能性磁性 MOFs 在分析其他含顺式二醇的目标方面具有很大的潜力，并且预安装策略可以适应 MOFs 的更广泛应用。