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Low dissolved oxygen increases uptake of a model calcium channel blocker and alters its effects on adult Pimephales promelas.
Comparative Biochemistry and Physiology C: Toxicology & Pharmacology ( IF 3.9 ) Pub Date : 2020-01-24 , DOI: 10.1016/j.cbpc.2020.108719
Gavin N Saari 1 , Samuel P Haddad 1 , Rachel M Mole 1 , Bridgett N Hill 1 , W Baylor Steele 2 , Lea M Lovin 1 , C Kevin Chambliss 3 , Bryan W Brooks 4
Affiliation  

Human population growth accompanied with urbanization is urbanizing the water cycle in many regions. Urban watersheds, particularly with limited upstream dilution of effluent discharges, represent worst case scenarios for exposure to multiple environmental stressors, including down the drain chemicals (e.g., pharmaceuticals) and other stressors (e.g., dissolved oxygen (DO)). We recently identified the calcium channel blocker diltiazem (DZM) to accumulate in fish plasma exceeding human therapeutic doses (e.g., Cmin) in coastal estuaries impaired due to nonattainment of DO water quality standards. Thus, we examined whether DO influences DZM uptake by fish, and if changes in DO-dependent upatke alter fish physiological and biochemical responses. Low DO (3.0 mg DO/L) approximately doubled diltiazem uptake in adult fathead minnows relative to normoxic (8.2 mg DO/L) conditions and were associated with significant (p < 0.05) increases in fish ventilation rate at low DO levels. Decreased burst swim performance (Uburst) of adult fathead minnows were significantly (p < 0.05) altered by low versus normal DO levels. DO × DZM studies reduced Uburst by 13-31% from controls, though not significantly (p = 0.06). Physiological responses in fish exposed to DZM alone were minimal; however, in co-exposure with low DO, decreasing trends in Uburst appeared inversely related to plasma lactate levels. Such physiological responses to multiple stressors, when paired with internal tissue concentrations, identify the utility of employing biological read across approaches to identify adverse outcomes of heart medications and potentially other cardiotoxicants impacting fish cardiovascular function across DO gradients.

中文翻译:

低溶解氧增加了模型钙通道阻滞剂的吸收,并改变了其对成虫吡美pro的影响。

伴随着城市化的人口增长正在使许多地区的水循环城市化。城市集水区,特别是上游排放物稀释程度有限,是暴露于多种环境压力源的最坏情况,包括向下排放的化学品(例如,药品)和其他压力源(例如,溶解氧(DO))。我们最近确定了钙通道阻滞剂地尔硫卓(DZM)积聚在由于未达到DO水质标准而受损的沿海河口中超过人类治疗剂量(例如Cmin)的鱼血浆中。因此,我们检查了溶解氧是否会影响鱼类对DZM的吸收,以及溶解氧依赖性upatke的变化是否会改变鱼类的生理和生化反应。低溶解氧(3。相对于常氧(8.2 mg DO / L)条件,0 mg DO / L)成年黑头min鱼地尔硫卓的摄入量大约增加了一倍,并且与低DO水平下的鱼类通气率显着增加(p <0.05)相关。低DO水平与正常DO水平相比,成年fat鱼min鱼的突然游泳性能(Uburst)降低显着(p <0.05)。DO×DZM研究使Uburst与对照组相比减少了13-31%,尽管没有显着降低(p = 0.06)。仅暴露于DZM的鱼的生理反应很小;然而,在低溶解氧的同时暴露下,Uburst的下降趋势似乎与血浆乳酸水平成反比。当与内部组织浓度配对时,对多种应激源的这种生理反应,
更新日期:2020-01-24
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