An efficient preparation of sulfamate-fused 2-aminopyrroles was achieved through an isocyanide-based three-component [1+2+2] annulation of isocyanides, dialkyl acetylenedicarboxylates, and sulfamate-derived cyclic imines in good to excellent yields (up to 99 %). This reaction proceeds smoothly without any activation or modification of substances under neutral and metal-free conditions. The reaction could also be conveniently performed on a gram scale.

中文翻译：

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通过基于异氰化物的三组分[1 + 2 + 2]环合成氨基磺酸氨基磺酸2-氨基吡咯。

通过异氰酸酯，二烷基乙酰二羧酸二烷基酯和氨基磺酸衍生的环状亚胺的异氰酸酯基三组分[1 + 2 + 2]环化，可以高效制备氨基磺酸盐稠合的2-氨基吡咯）。该反应在中性和无金属的条件下进行得很顺利，没有任何物质的活化或改性。该反应还可以方便地以克为单位进行。