Konjac glucomannan is a biocompatible polysaccharide with high medicinal potential. In this study, we prepared a hydrogel using an optimized crosslinking konjac glucomannan and chitosan. Silver nanoparticles (AgNPs) were incorporated into the hydrogel to enhance its antimicrobial property. This nanocomposite hydrogel could absorb wound exudates due to its swelling ability, and showed self-healing property that enabled structure stability. Moreover, as a carrier, the hydrogel could modulate the release of silver ions burst, thereby reducing AgNPs cytotoxicity. Rats models with infected skin defects were used to assess wound healing. The results indicated that AgNPs hydrogels dressing could promote wound healing and reduce inflammatory response, exhibiting great clinical application potentials.

魔芋葡甘露聚糖是具有高药用潜力的生物相容性多糖。在这项研究中，我们使用优化的交联魔芋葡甘露聚糖和壳聚糖制备了水凝胶。将银纳米颗粒（AgNPs）掺入到水凝胶中以增强其抗菌性能。这种纳米复合水凝胶由于其溶胀能力而可以吸收伤口渗出液，并显示出使结构稳定的自我修复特性。此外，作为载体，水凝胶可调节释放银离子的释放，从而降低AgNPs的细胞毒性。具有感染的皮肤缺陷的大鼠模型用于评估伤口愈合。结果表明，AgNPs水凝胶敷料可促进伤口愈合，减少炎症反应，具有很大的临床应用潜力。