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Human embryonic stem cell-derived neural stem cells encapsulated in hyaluronic acid promotes regeneration in a contusion spinal cord injured rat.
International Journal of Biological Macromolecules ( IF 8.2 ) Pub Date : 2020-01-23 , DOI: 10.1016/j.ijbiomac.2020.01.219
Masoumeh Zarei-Kheirabadi 1 , Hoda Sadrosadat 2 , Atiyeh Mohammadshirazi 1 , Razieh Jaberi 1 , Farzaneh Sorouri 3 , Fahimeh Khayyatan 4 , Sahar Kiani 1
Affiliation  

spinal cord injury (SCI) is a traumatic damage that can causes a loss of neurons around the lesion site and resulting in locomotor and sensory deficits. Currently, there is widely attempts in improvement of treatment strategy and cell delivering to the central nervous system (CNS). The usage of hyaluronic acid (HA), the main components of the ECM in CNS tissue and neural stem cells (NSCs) niche, is a good selection that can increase of viability and differentiation of NSCs. Importantly, we demonstrate that encapsulation of human embryonic stem cell derived-neural stem cells (hESC-NS) in HA-based hydrogel can increased differentiation these cells into oligodendrocytes and improved locomotor function.

中文翻译:

透明质酸封装的人胚胎干细胞衍生的神经干细胞促进挫伤脊髓损伤大鼠的再生。

脊髓损伤(SCI)是一种创伤性损伤,可引起病变部位周围的神经元丢失,并导致运动和感觉缺陷。当前,在改善治疗策略和将细胞递送至中枢神经系统(CNS)方面进行了广泛尝试。透明质酸(HA)是中枢神经系统组织和神经干细胞(NSCs)生态位中ECM的主要成分,它的使用是一种很好的选择,可以增加NSC的活力和分化。重要的是,我们证明在基于HA的水凝胶中封装人类胚胎干细胞衍生的神经干细胞(hESC-NS)可以增加将这些细胞分化为少突胶质细胞并改善运动功能。
更新日期:2020-01-23
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