Pure gelatin hydrogel (PG) has limited practical applications due to their thermal instability and unfavorable mechanical properties. To overcome these limitations, dually crosslinked hydrogels were developed by imparting chemical crosslinking to existing physically crosslinked gelatin hydrogel networks using succinoglycan dialdehyde (SGDA) as a macromolecular crosslinker. SGDA-reinforced gelatin hydrogels (SGDA/Gels) displayed an 11 times higher compressive stress under identical deformation strain and a 1040% improvement in storage modulus (G′) than PG. In addition, chemical crosslinking induced by SGDA increased the thermal stability of SGDA/Gels, such that they did not decompose at 60 °C, as confirmed by oscillatory temperature ramp experiments. The newly synthesized SGDA/Gels with reinforced networks and thermal stability exhibit potential for long-term use as controlled drug delivery carriers and 3D cell culture scaffolds for tissue engineering.

纯明胶水凝胶（PG）由于其热不稳定性和不利的机械性能而在实际应用中受到限制。为了克服这些限制，通过使用琥珀酸聚糖二醛（SGDA）作为大分子交联剂，对现有的物理交联的明胶水凝胶网络进行化学交联，从而开发出了双交联的水凝胶。SGDA增强的明胶水凝胶（SGDA / Gels）在相同的变形应变下显示出比PG高11倍的压缩应力，并且储能模量（G'）提高了1040％。另外，由SGDA诱导的化学交联增加了SGDA / Gels的热稳定性，从而使其在60°C时不会分解，这已通过振荡温度上升实验得到了证实。