Abstract

Xyloglucans are highly branched, hydroxyl rich polyglucans that for their abundance in nature, biocompatibility, film forming and gelation ability may take a prominent role in the design and fabrication of biomedical devices, including in situ forming scaffolds for tissue engineering, wound dressings and epidermal sensors. The understanding and exploitation of their self-assembly behavior is key for the device performance optimization. A multi-scale analysis, conducted combining small-angle X-ray scattering, both static and dynamic light scattering at large and small angles, and rheological measurements, provides a description of the supramolecular organization of this biopolymer, from the scale of a few nano-meter, to the meso- and macro-scale both in the sol and gel states. Xyloglucan self-assembly is described as multi-step and hierarchical process with different levels of organization.

中文翻译：

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木葡聚糖胶体分散体和水-醇凝胶的多尺度结构分析

摘要

木葡聚糖是高度支化的，富含羟基的聚葡聚糖，由于其丰富的性质，生物相容性，成膜和胶凝能力，可能在生物医学装置的设计和制造中发挥重要作用，包括用于组织工程，伤口敷料和表皮传感器的原位形成支架。了解和利用它们的自组装行为是优化设备性能的关键。结合小角度X射线散射，大和小角度的静态和动态光散射以及流变学测量进行的多尺度分析，从几纳米的尺度描述了这种生物聚合物的超分子组织。米，在溶胶和凝胶状态下均达到中观和宏观尺度。