OBJECTIVES Clozapine (CLZ) is prescribed to (relatively) treatment-resistant patients with schizophrenia spectrum disorders. Currently, it is unknown what factors predict response to CLZ. Therefore, we performed meta-analyses to identify predictors of CLZ response, hence aiming to facilitate timely and efficient prescribing of CLZ. METHODS A systematic search was performed in 'Pubmed' and 'Embase' until 1 January 2019. Articles were eligible if they provided data on predictors of CLZ response measured demographic and clinical factors at baseline or biochemical factors at follow-up in schizophrenia spectrum disorder patients. RESULTS A total of 34 articles, total number of participants = 9386; N unique = 2094, were eligible. Factors significantly associated with better CLZ response were: lower age, lower PANSS negative score and paranoid schizophrenia subtype. CONCLUSION The results of our meta-analyses suggest that three baseline demographic and clinical features are associated with better clozapine response, i.e. relatively young age, few negative symptoms and paranoid schizophrenia subtype. These variables may be taken into account by clinicians who consider treating a specific patient with CLZ.

中文翻译：

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人口统计学和临床​​特征可预测精神分裂症频谱疾病患者的氯氮平反应：系统评价和荟萃分析。

目的氯氮平（CLZ）用于治疗精神分裂症频谱障碍的患者（相对）。目前，尚不清楚什么因素预测对CLZ的反应。因此，我们进行了荟萃分析，以确定CLZ反应的预测因素，从而旨在促进及时有效地开具CLZ。方法对“ Pubmed”和“ Embase”进行系统搜索直至2019年1月1日。如果文章提供了精神分裂症谱系障碍患者基线时测量的CLZ反应的人口统计学和临床​​因素或生化因素的预测因素，则该文章符合条件。 。结果共有34篇文章，参加者总数= 9386；N个唯一身份= 2094，符合条件。与改善CLZ效果显着相关的因素包括：年龄较低，较低的PANSS阴性评分和偏执型精神分裂症亚型。结论我们的荟萃分析结果表明，三种基线人口统计学和临床​​特征与氯氮平反应较好有关，即年龄相对较小，阴性症状少和偏执型精神分裂症亚型。考虑考虑治疗CLZ特定患者的临床医生可以考虑这些变量。