Oxidative stress in the tumor microenvironment activates expression of the phosphatase PAC1 in infiltrated T lymphocytes. PAC1 regulates the epigenetic modulator NuRD to limit the chromatin accessibility of T cell effector function genes, thereby fostering T cell exhaustion.

中文翻译：

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PAC1-促进表观遗传

肿瘤微环境中的氧化应激激活了浸润的T淋巴细胞中磷酸酶PAC1的表达。PAC1调节表观遗传调节剂NuRD，以限制T细胞效应子功能基因的染色质可及性，从而促进T细胞衰竭。