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Attenuation of diabetic retinopathy and neuropathy by resveratrol: Review on its molecular mechanisms of action.
Life Sciences ( IF 6.1 ) Pub Date : 2020-01-23 , DOI: 10.1016/j.lfs.2020.117350
Irshad Ahmad 1 , Muddasarul Hoda 2
Affiliation  

Resveratrol is an important phenolic phytochemical from the therapeutic perspective. It has therapeutic impacts over wide range of diseases, especially the ones related to oxidative stress. Resveratrol, being primarily a potent anti-oxidant phytochemical, has significant impact against major diseases as inflammatory disorders, diabetes, and cancer. In the current review article, we intend to highlight the molecular aspects of the mechanism of action of resveratrol against major diabetic implications, namely, retinopathy and neuropathy. Both these diabetic implications are among the first fallouts of chronic hyperglycaemia. Resveratrol, via multiple molecular pathways, tend to attenuate and reverse these deformity and other disease-causing implications.

中文翻译:

白藜芦醇对糖尿病性视网膜病变和神经病变的缓解作用:其作用机理的综述。

从治疗的角度来看,白藜芦醇是重要的酚类植物化学物质。它对多种疾病,尤其是与氧化应激有关的疾病具有治疗作用。白藜芦醇主要是一种有效的抗氧化剂植物化学物质,对诸如炎性疾病,糖尿病和癌症等主要疾病具有重大影响。在当前的综述文章中,我们打算强调白藜芦醇针对主要糖尿病隐喻(即视网膜病变和神经病变)的作用机理的分子方面。这两种糖尿病的影响都属于慢性高血糖症的首例后果。白藜芦醇通过多种分子途径趋向于减轻和逆转这些畸形和其他致病隐患。
更新日期:2020-01-23
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