Green synthesis of hexamethylene-1,6-dicarbamate (HDC) by reacting 1,6-hexanediamine with dimethyl carbonate (DMC) has garnered considerable attention recently because of the usage of DMC, which substitutes toxic phosgene. In this study, some plant-wide processes are proposed for green HDC synthesis. In the first process, HDC is synthesized using two reactive distillation (RD) columns in series. Excess DMC is used and the mixture of unreacted DMC and byproduct methanol from the RD column tops is separated by using a series of conventional distillation columns. Next, each RD column is enhanced by vapor recompression (VR) to reduce energy consumption by fully utilizing a small temperature difference between the column bottom and top. By the latent heat released from the overhead vapors of the RD columns, VR eliminates all reboiler duties of RD columns and conserves a substantial energy demand from conventional distillation columns. Compared with the process designed by RD, the process designed by RD + VR can reduce total operation cost and total annual cost by 42.6 % and 34.6 %, respectively. Finally, HDC synthesis by using CSTR is designed to compare with the RD- and RD + VR-intensified processes. Simulation results demonstrate that the reactive VR distillation process provides the most economical design for green HDC synthesis.

通过使1，6-己二胺与碳酸二甲酯（DMC）反应，绿色合成六亚甲基-1,6-二氨基甲酸酯（HDC）已引起广泛关注，这是因为使用了DMC来代替有毒的光气。在这项研究中，提出了一些用于绿色HDC合成的全厂范围的工艺。在第一个过程中，使用两个串联的反应蒸馏（RD）柱合成HDC。使用过量的DMC，并且通过使用一系列常规蒸馏塔分离来自RD塔顶部的未反应的DMC和副产物甲醇的混合物。接下来，通过充分利用塔底和塔顶之间的较小温差，通过蒸汽压缩（VR）增强每个RD色谱柱，从而降低能耗。通过RD塔顶部蒸气释放的潜热，VR消除了RD塔的所有再沸器职责，并节省了常规蒸馏塔的大量能源需求。与RD设计的过程相比，RD + VR设计的过程可以分别降低总运营成本和总年度成本42.6％和34.6％。最后，设计了使用CSTR的HDC合成，以与RD和RD + VR增强工艺进行比较。仿真结果表明，反应式VR蒸馏过程为绿色HDC合成提供了最经济的设计。通过使用CSTR进行HDC合成的目的是与RD和RD + VR增强的工艺进行比较。仿真结果表明，反应式VR蒸馏过程为绿色HDC合成提供了最经济的设计。通过使用CSTR进行HDC合成的目的是与RD和RD + VR增强的工艺进行比较。仿真结果表明，反应式VR蒸馏过程为绿色HDC合成提供了最经济的设计。