Co-cultivation of viable cells of the human pathogenic bacterium Pseudomonas aeruginosa with the endophytic fungus Fusarium tricinctum induced silent bacterial biosynthetic gene clusters. Visual and chemical inspection of the co-cultures by comparison with the axenic cultures showed a clear reaction of P. aeruginosa towards its fungal competitor which was reflected by the deep greenish coloration of the co-cultures. Inspection of the HPLC chromatograms of the co-cultures revealed the induction of the pseudomonal quorum sensing molecule 2-heptyl-4-hydroxy-quinolone (HHQ) along with the antifungal phenazine alkaloids, phenazine-1-carboxylic acid (PCA) and phenazine-1-carboxamide (PCN), which are well-known metabolites of P. aeruginosa. The latter compounds were not detected in axenic bacterial cultures. In contrast to P. aeruginosa, no metabolic responses were detected for F. tricinctum which is in sharp contrast to previous co-culture experiments with this fungus using other bacteria.

人类致病性细菌铜绿假单胞菌的活细胞与内生真菌镰刀菌诱导的沉默细菌生物合成基因簇的共同培养。通过与轴突培养物的比较，对共培养物的视觉和化学检查显示铜绿假单胞菌对其真菌竞争者有明显的反应，这由共培养物的深绿色着色反映出来。共培养物的HPLC色谱图检查显示，假单抗群体感应分子2-庚基-4-羟基喹诺酮（HHQ）以及抗真菌吩嗪生物碱，吩嗪-1-羧酸（PCA）和吩嗪- 1-羧酰胺（PCN）是铜绿假单胞菌的知名代谢产物。后者的化合物未在轴突细菌培养物中检测到。与铜绿假单胞菌相反，未检测到细小镰刀菌的代谢反应，这与之前使用该真菌与其他细菌的共培养实验形成鲜明对比。