当前位置: X-MOL 学术Arterioscler. Thromb. Vasc. Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Arterial Stiffness Accelerates Within 1 Year of the Final Menstrual Period: The SWAN Heart Study.
Arteriosclerosis, Thrombosis, and Vascular Biology ( IF 8.7 ) Pub Date : 2020-01-23 , DOI: 10.1161/atvbaha.119.313622
Saad Samargandy 1 , Karen A Matthews 2 , Maria M Brooks 1 , Emma Barinas-Mitchell 1 , Jared W Magnani 3 , Imke Janssen 4 , Steven M Hollenberg 5 , Samar R El Khoudary 1
Affiliation  

OBJECTIVE Menopause may augment age-dependent increases in arterial stiffness, with black women having greater progression in midlife compared with white women. We sought to determine whether and when women experience changes in arterial stiffness relative to the final menstrual period (FMP) and whether these changes differ between black and white midlife women. Approach and Results: We evaluated 339 participants from the SWAN Heart Ancillary study (Study of Women's Health Across the Nation). Women had ≤2 carotid-femoral pulse-wave velocity (cfPWV) exams over a mean±SD of 2.3±0.5 years of follow-up. Annual percentage changes in cfPWV were estimated in 3 time segments relative to FMP and compared using piecewise linear mixed-effects models. At baseline, women were 51.1±2.8 years of age and 36% black. Annual percentage change (95% CI) in cfPWV varied by time segments: 0.9% (-0.6% to 2.3%) for >1 year before FMP, 7.5% (4.1%-11.1%) within 1 year of FMP, and -1.0% (-2.8% to 0.8%) for >1 year after FMP. Annual percentage change in cfPWV within 1 year of FMP was significantly greater than the other 2 time segments; P<0.05 for both comparisons. Adjusting for concurrent cardiovascular disease risk factors explained part of the change estimates but did not eliminate the difference. Black women had greater increase in cfPWV compared with white women in the first segment; P for interaction, 0.04. CONCLUSIONS The interval within 1 year of FMP is a critical period for women when vascular functional alterations occur. These findings underscore the importance of more intensive lifestyle modifications in women transitioning through menopause.

中文翻译:

在末次月经期的1年内,动脉僵硬度会加快:SWAN心脏研究。

目的更年期可能会增加年龄依赖性的动脉僵硬度增加,黑人女性的中年进展要高于白人女性。我们试图确定女性是否以及何时经历相对于最终月经期(FMP)的动脉僵硬度的变化,以及这些变化在黑人和白人中年女性之间是否有所不同。方法和结果:我们评估了SWAN心脏辅助研究(全国妇女健康研究)中的339名参与者。在2.3±0。5年的随访中,妇女的颈动脉-股动脉脉搏波速度(cfPWV)≤2。相对于FMP,在3个时间段内估算了cfPWV的年度百分比变化,并使用分段线性混合效应模型进行了比较。基线时,女性为51.1±2.8岁,黑人为36%。cfPWV的年度百分比变化(95%CI)随时间段而变化:FMP之前> 1年的0.9%(-0.6%至2.3%),FMP一年内的7.5%(4.1%-11.1%)和-1.0 FMP后> 1年的%(-2.8%至0.8%)。FMP一年内cfPWV的年度百分比变化显着大于其他两个时间段;对于两个比较,P <0.05。调整并发的心血管疾病危险因素可以解释部分变化估计,但不能消除差异。在第一部分中,黑人妇女比白人妇女的cfPWV增加更大;P表示互动,0.04。结论FMP的1年内间隔是发生血管功能改变的女性的关键时期。这些发现强调了在更年期过渡的女性中进行更深入的生活方式改变的重要性。
更新日期:2020-03-26
down
wechat
bug