OBJECTIVE To determine the spectrum of phenotypes linked to the ABO blood group system, using genetic determinants of the ABO blood group system. Approach and Results: We assessed the risk of 41 health and disease outcomes, and 36 linear traits associated with the ABO blood group system in the UK Biobank cohort. A total of 406 755 unrelated individuals were included in this study. Blood groups A, B, and O were determined based on allele combinations of previously established single-nucleotide polymorphisms rs8176746, rs8176719 in the ABO gene. Group AB was excluded because of its relative small sample size. Overall, 187 387 (46%) were male with a mean (SD) age of 57±8.1 years and a median total exposure of 64 person-years (interquartile range, 57-70). Of 406 755 individuals, 182 621 (44.9%) participants had blood group O, 182 786 (44.9%) had blood group A, and 41 348 (10.2%) had blood group B. ABO blood groups were associated with 11 health and disease outcomes (P<2.19×10-4). ABO blood groups were primarily associated with cardiovascular outcomes. Compared with individuals with blood group O, blood groups A and B were associated with increased odds of up to 1.56 (95% CI, 1.43-1.69) for thromboembolic events and decreased odds for hypertension (0.94 [95% CI, 0.92-0.97]). CONCLUSIONS The ABO blood group system is associated with several parameters of healthy aging and disease development. Knowledge of ABO blood groups might be of interest for more personalized approaches towards health maintenance and the prevention of diseases.

中文翻译：

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基因确定的ABO血型及其与健康和疾病的关联。

目的利用ABO血型系统的遗传决定因素确定与ABO血型系统相关的表型谱。方法和结果：我们评估了英国生物银行队列中41种健康和疾病结果以及36种与ABO血型系统相关的线性特征的风险。本研究共纳入406755名无关个体。根据ABO基因中先前建立的单核苷酸多态性rs8176746，rs8176719的等位基因组合确定血型A，B和O。由于AB组样本量相对较小，因此被排除在外。总体而言，男性为187387名（46％），平均（SD）年龄为57±8.1岁，中位总暴露量为64人年（四分位间距为57-70）。在406755个人中，有182621（44.9％）人的O型血为182786（44。ABO血型占9％），B血型占41348（10.2％）。ABO血型与11种健康和疾病结果相关（P <2.19×10-4）。ABO血型主要与心血管结局有关。与具有O型血的个体相比，A和B型血栓栓塞事件的几率高达1.56（95％CI，1.43-1.69），而高血压的几率降低（0.94 [95％CI，0.92-0.97] ）。结论ABO血型系统与健康衰老和疾病发展的几个参数有关。了解ABO血型可能对健康维护和疾病预防的个性化方法感兴趣。ABO血型主要与心血管结局有关。与O型血的个体相比，A和B型血栓栓塞事件的几率增加至1.56（95％CI，1.43-1.69），而高血压的几率降低（0.94 [95％CI，0.92-0.97] ）。结论ABO血型系统与健康衰老和疾病发展的几个参数有关。了解ABO血型可能对健康维护和疾病预防的个性化方法感兴趣。ABO血型主要与心血管结局有关。与O型血的个体相比，A和B型血栓栓塞事件的几率增加至1.56（95％CI，1.43-1.69），而高血压的几率降低（0.94 [95％CI，0.92-0.97] ）。结论ABO血型系统与健康衰老和疾病发展的几个参数有关。了解ABO血型可能对健康维护和疾病预防的个性化方法感兴趣。结论ABO血型系统与健康衰老和疾病发展的几个参数有关。了解ABO血型可能对健康维护和疾病预防的个性化方法感兴趣。结论ABO血型系统与健康衰老和疾病发展的几个参数有关。了解ABO血型可能对健康维护和疾病预防的个性化方法感兴趣。