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Serum concentrations of persistent organic pollutants and the metabolic syndrome in Akwesasne Mohawks, a Native American community.
Environmental Pollution ( IF 8.9 ) Pub Date : 2020-01-23 , DOI: 10.1016/j.envpol.2020.114004
Zafar Aminov 1 , David O Carpenter 2
Affiliation  

The metabolic syndrome (MetS) is a group of diseases that tend to occur together, including diabetes, hypertension, central obesity, cardiovascular disease and hyperlipidemia. Exposure to persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) has been associated with increased risk of development of several of the components of the MetS. The goal of this study is to determine whether the associations with POPs are identical for each of the components and for the MetS. The subject population was 601 Native Americans (Akwesasne Mohawks) ages 18 to 84 who answered a questionnaire, were measured for height and weight and provided blood samples for clinical chemistries (serum lipids and fasting glucose) and analysis of 101 PCB congeners and three OCPs [dichlorodiphenyldichloroethylene (DDE), hexachlorobenzene (HCB) and mirex]. Associations between concentrations of total PCBs and pesticides, as well as various PCB congener groups with each of the different components of the MetS were determine so as to ask whether there were similar risk factors for all components of the MetS. After adjustment for other contaminants, diabetes and hypertension were strongly associated with lower chlorinated and mono-ortho PCBs, but not other PCB groups or pesticides. Obesity was most closely associated with highly chlorinated PCBs and was negatively associated with mirex. High serum lipids were most strongly associated with higher chlorinated PCBs and PCBs with multiple ortho-substituted chlorines, as well as total pesticides, DDE and HCB. Cardiovascular disease was not closely associated with levels of any of the measured POPs. While exposure to POPs is associated with increased risk of most of the various diseases comprising the MetS, the specific contaminants associated with risk of the component diseases are not the same.



中文翻译:

美洲原住民社区 Akwesasne Mohawks 中持久性有机污染物的血清浓度和代谢综合征。

代谢综合征(MetS)是一组往往同时发生的疾病,包括糖尿病、高血压、中心性肥胖、心血管疾病和高脂血症。接触持久性有机污染物 (POP),例如多氯联苯 (PCB) 和有机氯杀虫剂 (OCP),与 MetS 的几种成分的发展风险增加有关。本研究的目的是确定每个成分和 MetS 与 POP 的关联是否相同。受试者群体为 601 名年龄在 18 至 84 岁之间的美洲原住民 (Akwesasne Mohawks),他们回答了一份问卷,测量了身高和体重,并提供了用于临床化学(血清脂质和空腹血糖)的血液样本以及 101 种 PCB 同源物和 3 种 OCP 的分析。二氯二苯基二氯乙烯 (DDE)、六氯苯 (HCB) 和灭蚁灵]。确定总 PCB 和农药的浓度以及各种 PCB 同系物组与 MetS 的每种不同成分之间的关​​联,以询问 MetS 的所有成分是否存在相似的风险因素。对其他污染物进行调整后,糖尿病和高血压与低氯化和单邻位多氯联苯密切相关,但与其他多氯联苯组或农药无关。肥胖与高度氯化的多氯联苯关系最为密切,与灭蚁灵呈负相关。高血脂与较高氯化 PCB 和具有多个邻位取代氯的 PCB 以及总农药、DDE 和 HCB密切相关。心血管疾病与任何测得的持久性有机污染物的水平都没有密切关系。虽然接触持久性有机污染物与构成 MetS 的大多数各种疾病的风险增加有关,但与组成疾病的风险相关的具体污染物并不相同。

更新日期:2020-01-23
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