The synthesis of zinc (II) tri (tert-butyl phenoxy) mono cinnamic acid Pc (complex 1) is reported for the first time in this work. Complex 1 and the reported zinc (II) tri (tert-butyl), mono cinnamic acid phthalocyanine (2), zinc (II) mono cinnamic acid substituted phthalocyanine (3) and zinc (II) tetra cinnamic acid substituted phthalocyanine (4) are conjugated to cysteine capped silver nanoparticles (cys-AgNPs) through an amide bond. The photophysicochemical properties and the photodynamic antimicrobial chemotherapy (PACT) activities of the Pc-cys-AgNPs conjugates and the Pcs alone on S. Aureus are reported. Improved triplet and singlet oxygen quantum yields were observed for the conjugated complexes compared to Pcs alone, due to the heavy atom effect of cys-AgNPs. Asymmetric complexes 1,2, 3 and their respective conjugates recorded higher photosensitizing properties and PACT activities compared to 4 and 4-cys-AgNPs, respectively. Higher log reductions and percentage reductions of S. Aureus were recorded for conjugated complexes compared to ZnPcs only, showing enhanced PACT activities due to their higher singlet oxygen quantum yield.

这项工作中首次报道了锌（II）三（叔丁基苯氧基）单肉桂酸Pc（配合物1）的合成。配合物1和已报道的锌（II）三（叔丁基），单肉桂酸酞菁（2），锌（II）单肉桂酸取代的酞菁（3）和锌（II）四肉桂酸取代的酞菁（4）是通过酰胺键与半胱氨酸封端的银纳米颗粒（cys-AgNPs）偶联。Pc-cys-AgNPs共轭物和单独的Pcs在金黄色葡萄球菌上的光物理化学特性和光动力抗菌化学（PACT）活性被报道。由于cys-AgNPs的重原子效应，与单独的Pcs相比，共轭复合物的三重态和单重态氧量子产率提高。与4和4-cys-AgNPs相比，不对称复合物1,2、3及其各自的结合物分别具有更高的光敏特性和PACT活性。与仅ZnPcs相比，共轭复合物的金黄色葡萄球菌对数减少率和百分比减少率更高，显示出PACT活性增强，因为它们的单线态氧量子产率更高。