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Repurposing biodegradable tissue engineering scaffolds for localized chemotherapeutic delivery.
Journal of Biomedical Materials Research Part A ( IF 4.9 ) Pub Date : 2020-02-03 , DOI: 10.1002/jbm.a.36889
Erika L Cyphert 1 , Monika Bil 2 , Horst A von Recum 1 , Wojciech Święszkowski 2
Affiliation  

While highly porous biodegradable sponges have typically been used as tissue engineering scaffolds, they could be applicable in settings requiring drug delivery. Since most drug delivery devices are intentionally solid, nonporous polymers, a detailed structure–function relationship of delivery from a porous degradable sponges would allow researchers to develop such devices for either delivery alone, or in conjunction with tissue engineering. Two fabrication techniques (salt‐leaching and solvent‐quenching) were used to prepare several different variations of poly(DL‐lactide‐glycolide) and poly(caprolactone)‐co‐poly(lactide) porous sponges. Upon fabrication, an in‐depth structure–function analysis was carried out where the functions of loading capacity and release profile of cisplatin, as a model drug, were evaluated in terms of the swelling, porosity, and degradation properties of the sponges. Swelling, pore volume fraction, and the number of pores per volume were all found to be positively correlated with both the loading capacity and amount of cisplatin released after 2 hr. Knowledge of these relationships can be used to assist in the design of other porous delivery systems.

中文翻译:

重新利用可生物降解的组织工程支架用于局部化疗递送。

虽然高度多孔的可生物降解海绵通常被用作组织工程支架,但它们可适用于需要药物输送的环境。由于大多数药物输送装置是有意为固体、无孔聚合物,从多孔可降解海绵输送的详细结构-功能关系将允许研究人员开发此类装置,用于单独输送或与组织工程结合使用。两种制造技术(盐浸和溶剂淬火)用于制备聚(DL-丙交酯-乙交酯)和聚(己内酯)-共聚(丙交酯)多孔海绵的几种不同变体。在制造时,进行了深入的结构 - 功能分析,其中顺铂作为模型药物的负载能力和释放曲线的功能在膨胀方面进行了评估,海绵的孔隙率和降解特性。膨胀、孔体积分数和每体积孔数都被发现与负载能力和 2 小时后释放的顺铂量呈正相关。这些关系的知识可用于帮助设计其他多孔递送系统。
更新日期:2020-02-03
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