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Efficient reactions for the synthesis of pyrazolo[3,4‐b]pyridine and pyrano[2,3‐c]pyrazole derivatives from N‐methyl‐1‐(methylthio)‐2‐nitroethen‐1‐amine
Journal of Heterocyclic Chemistry ( IF 2.4 ) Pub Date : 2020-01-23 , DOI: 10.1002/jhet.3903
Yifan Ji 1 , Li Li 1 , Guangzhou Zhu 1 , Ya Zhou 1 , Xinchi Lu 1 , Wenjing He 1 , Lijiu Gao 1 , Liangce Rong 1
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The efficient and novel method for the synthesis of pyrazolo[3,4‐b]pyridine and pyrano[2,3‐c]pyrazole derivatives from the multicomponent reaction of aromatic aldehydes (isatins), N‐methyl‐1‐(methylthio)‐2‐nitroethen‐1‐amine, and 3‐aminopyrazole or methyl 3‐hydroxy‐1H‐pyrazole‐5‐carboxylate under normal laboratory conditions was reported in this research. The advantages of this research are wide range of substrates, high yields, and simple operation.

中文翻译:

由N-甲基-1-(甲硫基)-2-硝基乙炔-1-胺合成吡唑并[3,4-b]吡啶和吡喃并[2,3-c]吡唑衍生物的有效反应

由芳族醛(isatins),N-甲基-1-(甲硫基)-多组分反应合成吡唑并[3,4- b ]吡啶和吡喃并[2,3- c ]吡唑衍生物的有效新颖方法在这项研究中,报告了在正常实验室条件下使用2-硝基乙烯-1-胺和3-氨基吡唑或3-羟基-1 H-吡唑-5-羧酸甲酯。这项研究的优点是基板范围广,产量高,操作简单。
更新日期:2020-01-23
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