BACKGROUND There are large individual differences in physical activity (PA) behavior as well as trainability of physical capacity. Heritability studies have shown that genes may have as much impact on exercise participation behavior as environmental factors. Genes that favor both trainability and participation may increase the levels of PA. The present study aimed to assess the allele frequencies in genes associated with PA and/or physical capacity, and to see if there is any association between these polymorphisms and self-reported PA levels in a cohort of middle-aged Norwegians of Scandinavian descent (n = 831; mean age mean age (± SD) 55.5 ± 3.8 years). RESULTS The genotype distributions of the ACTN3 R577X, ACE I/D and MAOA uVNTR polymorphisms were similar to other populations of European descent. When comparing the genotype distribution between the low/medium level PA group (LMPA) and high level PA groups (HPA), a significant difference in ACTN3 577X allele distribution was found. The X allele frequency was 10% lower in the HPA level group (P = 0.006). There were no differences in the genotype distribution of the ACE I/D or MAOA uVNTR polymorphism. Education and previous participation in sports or outdoor activities was positively associated with the self-reported PA levels (P ≤ 0.001). CONCLUSIONS To the best of our knowledge, this is the first study to report association between ACTN3 R577X genotype and PA level in middle-aged Scandinavians. Nevertheless, the contribution of a single polymorphism to a complex trait, like PA level, is likely small. Socioeconomic variables, as education and previous participation in sports or outdoor activities, are positively associated with the self-reported PA levels.

中文翻译：

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在同质的挪威队列研究中，与体育活动和/或体育活动能力相关的基因的等位基因频率分布。

背景技术在体育活动（PA）行为以及体育能力的可训练性方面存在很大的个体差异。遗传性研究表明，基因对运动参与行为的影响可能与环境因素一样多。有利于训练和参与的基因可能会增加PA的水平。本研究旨在评估与PA和/或体力相关的基因中的等位基因频率，并查看这些多态性与自我报告的PA水平之间是否存在关联，该群体来自挪威中裔后裔群体（n = 831；平均年龄平均年龄（±SD）55.5±3.8岁）。结果ACTN3 R577X，ACE I / D和MAOA uVNTR多态性的基因型分布与其他欧洲血统人群相似。比较低/中水平PA组（LMPA）和高水平PA组（HPA）之间的基因型分布时，发现ACTN3 577X等位基因分布存在显着差异。HPA水平组的X等位基因频率降低10％（P = 0.006）。ACE I / D或MAOA uVNTR多态性的基因型分布没有差异。教育和以前参加运动或户外活动与自我报告的PA水平呈正相关（P≤0.001）。结论据我们所知，这是第一项报道ACTN3 R577X基因型与中年斯堪的纳维亚人PA水平相关性的研究。但是，单个多态性对复杂性状（如PA水平）的贡献可能很小。社会经济变量