AIM To study whether early intervention services (EI) and a follow-up program (FU) influence outcomes of children with cerebral palsy (CP) in Moldova. METHODS Records from 351 children with CP in Moldova born during 2009 and 2010 were retrieved from hospital and orphanage archives between 1 July 2016 and 30 September 2017. We investigated the proportion enrolled in EI and FU at the Early Intervention Centre Voinicel and at the Institute of Mother and Child in 2009-2012. Logistic regression analyses were applied to calculate crude and adjusted odds ratios (OR) with 95% confidence intervals (CI) for outcomes in children enrolled and not enrolled. RESULTS Among all children with CP, 166 (47%) were enrolled in EI and FU. Of the 51 children born extremely preterm (gestational age ≤ 31 weeks), 46 (90%) were enrolled, compared to 97 (39%) of the 250 children born at term. Among 110 non-walking children with CP, 82 (74%) were enrolled into EI and FU, compared to 84 (35%) of 241 able to walk. There was no difference in outcomes of cognition, communication, vision and hearing impairments between those enrolled or not enrolled in EI and FU. However, the subgroup analyses showed that the risk of contractures was 11 times higher among non-walking children who were not enrolled in EI and FU programs (OR = 10.931, 95% CI 2.328-51.328, p = 0.002). CONCLUSION In Moldova, EI and FU seem to be offered mostly to extremely preterm and non-walking children with CP. The results indicate a decreased risk for contractures in these children.

中文翻译：

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摩尔多瓦脑瘫患儿的早期干预和随访计划：对障碍的潜在影响？

目的研究摩尔多瓦的早期干预服务（EI）和后续计划（FU）是否会影响脑性瘫痪（CP）儿童的预后。方法在2016年7月1日至2017年9月30日期间，从医院和孤儿院档案中检索了2009年和2010年出生的351名摩尔多瓦CP儿童的记录。我们调查了Voinicel早期干预中心和美国爱滋病研究所的EI和FU入学比例。 2009-2012年的母子关系。应用Logistic回归分析计算入组和未入组儿童结局的原始和调整后的优势比（OR），置信区间（CI）为95％。结果在所有患有CP的儿童中，有166名（47％）加入EI和FU。在51名极端早产儿（胎龄≤31周）中，有46名（90％）入选，相比之下，足月出生的250名儿童中有97名（39％）。在110名非行走性CP儿童中，有82名（74％）参加了EI和FU，而241名能够行走的儿童中有84名（35％）。EI和FU参加者与未参加者之间在认知，沟通，视力和听力障碍的结局上没有差异。但是，亚组分析显示，未参加EI和FU计划的非学步儿童的挛缩风险高11倍（OR = 10.931，95％CI 2.328-51.328，p = 0.002）。结论在摩尔多瓦，EI和FU似乎主要提供给极早产和非行走性CP儿童。结果表明这些儿童发生挛缩的风险降低。EI和FU参加者与未参加者之间在认知，沟通，视力和听力障碍的结局上没有差异。但是，亚组分析显示，未参加EI和FU计划的非学步儿童的挛缩风险高11倍（OR = 10.931，95％CI 2.328-51.328，p = 0.002）。结论在摩尔多瓦，EI和FU似乎主要提供给极早产和非行走性CP儿童。结果表明这些儿童发生挛缩的风险降低。EI和FU参加者与未参加者之间在认知，沟通，视力和听力障碍的结局上没有差异。但是，亚组分析显示，未参加EI和FU计划的非学步儿童的挛缩风险高11倍（OR = 10.931，95％CI 2.328-51.328，p = 0.002）。结论在摩尔多瓦，EI和FU似乎主要提供给极早产和非行走性CP儿童。结果表明这些儿童发生挛缩的风险降低。亚组分析显示，未参加EI和FU计划的非学步儿童的挛缩风险高11倍（OR = 10.931，95％CI 2.328-51.328，p = 0.002）。结论在摩尔多瓦，EI和FU似乎主要提供给极早产和非行走性CP儿童。结果表明这些儿童发生挛缩的风险降低。亚组分析显示，未参加EI和FU计划的非学步儿童的挛缩风险高11倍（OR = 10.931，95％CI 2.328-51.328，p = 0.002）。结论在摩尔多瓦，EI和FU似乎主要提供给极早产和非行走性CP儿童。结果表明这些儿童发生挛缩的风险降低。