Purpose

The aim of this study was to determine whether the triglycerides and glucose (TyG) index is associated with the presence of metabolically obese normal-weight (MONW) phenotype and related cardiovascular risk factors.

Methods

Apparently healthy men and non-pregnant women aged 20–65 years were enrolled in a population-based cross-sectional study. Overweight, obesity, smoking, alcohol consumption, pregnancy, diagnosis of hypertension, diabetes, cardiovascular disease, liver disease, renal disease, malignancy, and medical treatment were exclusion criteria. Subjects were allocated into the MONW or normal-weight groups. MONW phenotype was defined by normal weight and the presence of at least one of the following cardiovascular risk factors: elevated blood pressure, hyperglycemia, hypertriglyceridemia, and low HDL cholesterol.

Results

A total of 542 subjects were enrolled and allocated into the MONW (n = 354) and normal-weight (n = 188) groups. The adjusted logistic regression analysis showed that the elevated TyG index is significantly associated with the presence of MONW phenotype (OR = 11.14; 95% CI 6.04–20.57), hyperglycemia (OR = 3.18; 95% CI 1.95–5.21), hypertriglyceridemia (OR = 399.19; 95% CI 94.01–1694.98), and low HDL-C (OR = 2.60; 95% CI 1.74–3.87), but not with elevated blood pressure (OR = 1.55; 95% CI 0.93–2.60).

Conclusion

Results of this study support that the TyG index may be a useful indicator to detect MONW phenotype and associated cardiovascular risk factors.

中文翻译：

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甘油三酸酯和葡萄糖指数与代谢型肥胖正常体重受试者的心血管危险因素有关。

目的

这项研究的目的是确定甘油三酸酯和葡萄糖（TyG）指数是否与代谢性肥胖正常体重（MONW）表型的存在和相关的心血管危险因素有关。

方法

年龄为20-65岁的显然健康的男性和未怀孕的女性参加了一项基于人群的横断面研究。超重，肥胖，吸烟，饮酒，怀孕，高血压，糖尿病，心血管疾病，肝病，肾病，恶性肿瘤和药物治疗是排除标准。将受试者分为MONW组或正常体重组。MONW表型由正常体重和以下至少一种心血管危险因素的存在定义：血压升高，高血糖，高甘油三酯血症和低HDL胆固醇。

结果

共有542名受试者入选，并分为MONW组（n  = 354）和正常体重组（n  = 188）。调整后的逻辑回归分析表明，升高的TyG指数与MONW表型的存在（OR = 11.14； 95％CI 6.04–20.57），高血糖症（OR = 3.18； 95％CI 1.95–5.21），高甘油三酯血症（OR = 399.19； 95％CI 94.01–1694.98）和低HDL-C（OR = 2.60； 95％CI 1.74–3.87），但血压升高时却没有（OR = 1.55； 95％CI 0.93-2.60）。

结论

这项研究的结果支持TyG指数可能是检测MONW表型和相关的心血管危险因素的有用指标。