Abstract

Porous silica nanoparticles (PSNs) were prepared by hydrolysis of tetraethyl orthosilicate and 3-aminopropyltriethoxysilane in emulsion. The PSN carriers with hierarchical pores are suitable for loading drug and controlling release. Chitosan molecules were used to close all drug-loaded pores to reduce the premature release. Hyaluronic acid (HA) modified carbon dots (CD_HA) are further used to encapsulate carriers, which endow them enzyme responsiveness. The PSN carriers display pH/enzyme-responsive release and the drug release follows the first-order kinetics model. CD_HA can be used not only for fluorescent marker for carriers, but also for qualitative monitoring of the drug release.

中文翻译：

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用于双重响应药物释放的多功能多孔二氧化硅纳米粒子

摘要

通过在乳液中水解原硅酸四乙酯和3-氨基丙基三乙氧基硅烷来制备多孔二氧化硅纳米粒子（PSN）。具有分层孔的PSN载体适合装载药物和控制释放。壳聚糖分子用于封闭所有载有药物的毛孔，以减少过早释放。透明质酸（HA）修饰的碳点（CD _HA）进一步用于封装载体，赋予载体酶反应性。PSN载体显示pH /酶响应释放，药物释放遵循一级动力学模型。CD _HA不仅可以用作载体的荧光标记，还可以用于药物释放的定性监测。