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Candida auris Biofilm Colonization on Skin Niche Conditions.
mSphere ( IF 4.8 ) Pub Date : 2020-02-26 , DOI: 10.1128/msphere.00972-19
Priya Uppuluri 1, 2
Affiliation  

Candida auris, an emerging multidrug-resistant yeast, has recently been associated with outbreaks of invasive infections in health care facilities worldwide. Its success as a nosocomial pathogen lies in its capability to sustain for prolonged periods in the intensive care unit (ICU), adeptly colonize skin, and spread among patients. Little is known of the mechanism behind the predilection of C. auris for skin or the extent of its resilience on it. Now, M. V. Horton, C. J. Johnson, J. F. Kernien, T. D. Patel, et al. (mSphere 5:e00910-19, 2020, ) demonstrate that in synthetic sweat medium designed to mimic axillary skin conditions, C. auris can grow into multilayers of cells called biofilms that can resist desiccation. C. auris’ propensity to form biofilms was further elaborated using a novel ex vivo porcine skin model of skin colonization. These studies provide early evidence that C. auris biofilm cells persisting on skin could serve as source of continuing outbreaks in health care facilities. Interventions blocking C. auris biofilm growth on skin will help control the spread of this pathogen. The views expressed in this article do not necessarily reflect the views of the journal or of ASM.

中文翻译:

皮肤生态位条件下的假丝酵母生物膜定殖。

新兴的耐多药性酵母菌假丝酵母最近与全球医疗机构爆发侵袭性感染有关。它作为医院病原体的成功在于其能够在重症监护病房(ICU)中长期维持,熟练地定居皮肤并在患者中传播的能力。人们对金黄色葡萄球菌偏爱皮肤的机制及其弹性的程度了解甚少。现在,MV Horton,CJ Johnson,JF Kernien,TD Patel等。(mSphere 5:e00910-19,2020,)证明,在旨在模拟腋窝皮肤状况的合成汗液培养基中,金黄色葡萄球菌可以生长成多层细胞,称为生物膜,可以抵抗干燥。使用新型的皮肤定植的离体猪皮肤模型,进一步阐明了金黄色葡萄球菌形成生物膜的倾向。这些研究提供了早期证据,表明持久存在于皮肤上的金黄色葡萄球菌生物膜细胞可能成为医疗机构持续暴发的来源。阻止皮肤上金黄色葡萄球菌生物膜生长的干预措施将有助于控制这种病原体的传播。本文中表达的观点不一定反映期刊或ASM的观点。
更新日期:2020-01-23
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