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An Electroencephalography Connectomic Profile of Posttraumatic Stress Disorder.
American Journal of Psychiatry ( IF 17.7 ) Pub Date : 2020-01-22 , DOI: 10.1176/appi.ajp.2019.18080911
Russell T Toll 1 , Wei Wu 1 , Sharon Naparstek 1 , Yu Zhang 1 , Manjari Narayan 1 , Brian Patenaude 1 , Carlo De Los Angeles 1 , Kasra Sarhadi 1 , Nicole Anicetti 1 , Parker Longwell 1 , Emmanuel Shpigel 1 , Rachael Wright 1 , Jennifer Newman 1 , Bryan Gonzalez 1 , Roland Hart 1 , Silas Mann 1 , Duna Abu-Amara 1 , Kamron Sarhadi 1 , Carena Cornelssen 1 , Charles Marmar 1 , Amit Etkin 1
Affiliation  

OBJECTIVE The authors sought to identify brain regions whose frequency-specific, orthogonalized resting-state EEG power envelope connectivity differs between combat veterans with posttraumatic stress disorder (PTSD) and healthy combat-exposed veterans, and to determine the behavioral correlates of connectomic differences. METHODS The authors first conducted a connectivity method validation study in healthy control subjects (N=36). They then conducted a two-site case-control study of veterans with and without PTSD who were deployed to Iraq and/or Afghanistan. Healthy individuals (N=95) and those meeting full or subthreshold criteria for PTSD (N=106) underwent 64-channel resting EEG (eyes open and closed), which was then source-localized and orthogonalized to mitigate effects of volume conduction. Correlation coefficients between band-limited source-space power envelopes of different regions of interest were then calculated and corrected for multiple comparisons. Post hoc correlations of connectomic abnormalities with clinical features and performance on cognitive tasks were conducted to investigate the relevance of the dysconnectivity findings. RESULTS Seventy-four brain region connections were significantly reduced in PTSD (all in the eyes-open condition and predominantly using the theta carrier frequency). Underconnectivity of the orbital and anterior middle frontal gyri were most prominent. Performance differences in the digit span task mapped onto connectivity between 25 of the 74 brain region pairs, including within-network connections in the dorsal attention, frontoparietal control, and ventral attention networks. CONCLUSIONS Robust PTSD-related abnormalities were evident in theta-band source-space orthogonalized power envelope connectivity, which furthermore related to cognitive deficits in these patients. These findings establish a clinically relevant connectomic profile of PTSD using a tool that facilitates the lower-cost clinical translation of network connectivity research.

中文翻译:

创伤后应激障碍的脑电图组学概况。

目的作者试图确定在创伤后应激障碍(PTSD)的战斗退伍军人和健康的战斗暴露的退伍军人之间,其频率特定的,正交的静止状态脑电功率包络连通性不同的大脑区域,并确定行为学差异的行为相关性。方法作者首先在健康对照组(N = 36)中进行了连通性方法验证研究。然后,他们对被部署到伊拉克和/或阿富汗的有或没有PTSD的退伍军人进行了两点病例对照研究。健康个体(N = 95)和满足PTSD完全阈值或亚阈值标准的个体(N = 106)进行了64通道静息EEG(睁眼和闭眼),然后对其进行源定位和正交处理以减轻体积传导的影响。然后计算感兴趣的不同区域的带限源空间功率包络之间的相关系数,并进行多次比较校正。进行了连接体异常与临床特征和认知任务表现的事后相关研究,以研究连接障碍性研究结果的相关性。结果PTSD的74个脑区连接明显减少(全部处于睁眼状态,并且主要使用theta载波频率)。眼眶和前额中前回的连通性最弱。数字跨度任务的性能差异映射到74个大脑区域对中的25个之间的连通性,包括背侧注意力,额前额叶控制和腹侧注意力网络的网络内连接。结论在θ带源空间正交功率包络连接中,明显存在与PTSD相关的异常异常,这与这些患者的认知缺陷有关。这些发现使用一种有助于建立低成本的网络连接研究的临床翻译工具来建立PTSD的临床相关结缔组织概况。
更新日期:2020-03-02
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