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Bottlebrush Bridge between Soft Gels and Firm Tissues
ACS Central Science ( IF 18.2 ) Pub Date : 2020-01-22 , DOI: 10.1021/acscentsci.9b01216
Andrew N. Keith 1 , Mohammad Vatankhah-Varnosfaderani 1 , Charles Clair 2 , Farahnaz Fahimipour 1 , Erfan Dashtimoghadam 1 , Abdelaziz Lallam 2 , Michael Sztucki 3 , Dimitri A. Ivanov 4, 5, 6 , Heyi Liang 7 , Andrey V. Dobrynin 7 , Sergei S. Sheiko 1
Affiliation  

Softness and firmness are seemingly incompatible traits that synergize to create the unique soft-yet-firm tactility of living tissues pursued in soft robotics, wearable electronics, and plastic surgery. This dichotomy is particularly pronounced in tissues such as fat that are known to be both ultrasoft and ultrafirm. However, synthetically replicating this mechanical response remains elusive since ubiquitously employed soft gels are unable to concurrently reproduce tissue firmness. We have addressed the tissue challenge through the self-assembly of linear–bottlebrush–linear (LBL) block copolymers into thermoplastic elastomers. This hybrid molecular architecture delivers a hierarchical network organization with a cascade of deformation mechanisms responsible for initially low moduli followed by intense strain-stiffening. By bridging the firmness gap between gels and tissues, we have replicated the mechanics of fat, fetal membrane, spinal cord, and brain tissues. These solvent-free, nonleachable, and tissue-mimetic elastomers also show enhanced biocompatibility as demonstrated by cell proliferation studies, all of which are vital for the safety and longevity of future biomedical devices.

中文翻译:

软凝胶和牢固组织之间的洗瓶桥

柔软度和紧实度似乎是不相容的特征,可协同创造出在软机器人,可穿戴电子设备和整形外科中所追求的独特的活组织柔软触感。这种二分法在诸如脂肪之类的已知既超软又超坚硬的组织中特别明显。然而,由于普遍使用的软凝胶不能同时复制组织的坚固性,因此合成复制这种机械反应仍然难以实现。我们已经通过将线性-刷子-线性(LBL)嵌段共聚物自组装成热塑性弹性体来解决组织挑战。这种混合分子体系结构提供了具有级联变形机制的分层网络组织,这些变形机制负责最初的低模量,随后是强烈的应变刚度。通过弥合凝胶和组织之间的牢固性差距,我们复制了脂肪,胎儿膜,脊髓和脑组织的力学原理。这些无溶剂,不可浸提和组织模拟的弹性体还显示出增强的生物相容性,如细胞增殖研究所证实的,所有这些对于未来生物医学设备的安全性和寿命至关重要。
更新日期:2020-03-26
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