Atherosclerosis is one of the main causes of cardiovascular diseases. Our previous study indicated that a type of peroxidase derived from foxtail millet bran (FMBP) had prominent antitumor activities. In the present study, we found that FMBP had potential antiatherosclerosis effects. The results showed that FMBP treatment strongly suppressed lipid phagocytosis in both HASMCs and THP-1 cells by 52% and 49%, respectively. Further, FMBP significantly inhibited HASMCs migration by promoting transformation of HASMCs from synthetic to contractile, leading to the decrease of lipid phagocytosis. Simultaneously, FMBP repressed lipid uptake by reducing the expression of CD36 in THP-1 cells. In addition, FMBP reduced the secretion of inflammatory factor IL-1β by inhibiting the expression of STAT3 in THP-1 cells. Interestingly, FMBP also had the same effects in models of atherosclerosis constructed with ApoE-/- mice, including decreased aortic lesion area, repressed aortic sinus CD36 and STAT3 expression, and elevated serum HDL-C concentration. Collectively, these results indicate that FMBP has great potential in preventing the development of atherosclerosis.

中文翻译：

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谷子麸皮衍生的过氧化物酶的治疗通过体内和体外抑制CD36和STAT3来减轻动脉粥样硬化。

动脉粥样硬化是心血管疾病的主要原因之一。我们先前的研究表明，一种源自谷尾米糠（FMBP）的过氧化物酶具有显着的抗肿瘤活性。在本研究中，我们发现FMBP具有潜在的抗动脉粥样硬化作用。结果表明，FMBP处理分别强烈抑制HASMCs和THP-1细胞的脂质吞噬作用，分别为52％和49％。此外，FMBP通过促进HASMC从合成到收缩的转化而显着抑制HASMC迁移，从而导致脂质吞噬作用的降低。同时，FMBP通过减少THP-1细胞中CD36的表达来抑制脂质的摄取。此外，FMBP通过抑制THP-1细胞中STAT3的表达来减少炎症因子IL-1β的分泌。有趣的是 FMBP在用ApoE-/-小鼠构建的动脉粥样硬化模型中也具有相同的作用，包括减少主动脉病变面积，抑制主动脉窦CD36和STAT3表达以及升高血清HDL-C浓度。总的来说，这些结果表明FMBP在预防动脉粥样硬化发展方面具有巨大潜力。