Oral microbes are a contributing factor to hyperglycemia by inducing an increase in insulin resistance resulting in uncontrolled blood glucose levels. However, the relationship between the distribution of oral flora and hyperglycemia is still controversial. Combining the power of MALDI-Biotyper with anaerobic bacterial culture, this study explores the correlation between anaerobic bacteria in the oral cavity and blood glucose levels. The results demonstrated that altered blood glucose levels contributed to a varied bacterial distribution in the oral cavity. Specifically, Veillonella spp. and Prevotella spp. were identified in a higher proportion in people with elevated blood glucose levels. Six bacterial species identified in this study (Prevotella melaninogenica, Campylobacter rectus, Streptococcus gordonii, Streptococcus mitis, Streptococcus salivarius, and Veillonella parvula) not only demonstrated a positive association with higher blood glucose levels, but also likely contribute to the development of the condition. The data demonstrated MALDI-TOF MS to be a simpler, faster, and more economical clinical identification tool that provides clarity and depth to the research on blood glucose and oral microbiota.

口服微生物通过引起胰岛素抵抗增加，导致血糖水平不受控制而成为高血糖症的成因。但是，口腔菌群分布与高血糖之间的关系仍存在争议。结合MALDI-Biotyper与厌氧细菌培养的能力，本研究探讨了口腔中厌氧细菌与血糖水平之间的相关性。结果表明，血糖水平的改变导致口腔中细菌分布的变化。特别是Veillonella spp。和Prevotella spp。在血糖水平升高的人群中比例更高。本研究中鉴定出六种细菌（黑色素水杆菌），直肠弯曲杆菌，链球菌戈登，缓症链球菌，唾液链球菌，和小韦荣菌）不仅展示了较高的血糖水平呈正相关，但也有可能导致病情的发展。数据表明，MALDI-TOF MS是一种更简单，更快速，更经济的临床鉴定工具，为血糖和口腔微生物群的研究提供了清晰性和深度。