Hydroxyapatite (HA) is a traditional bone repair material, but its poor osteogenic and angiogenic abilities hinder the clinical application for critical-sized bone defect healing. Herein, ytterbium-doped hydroxyapatite (YbHA) nanorod arrays in situ deposited in magnetic chitosan (CS) porous scaffolds, leading to create magnetic YbHA/CS (MYbHA/CS) nanohybrid scaffolds. We hypothesized that both magnetic SrFe₁₂O₁₉ nanoplates and Yb dopants in the functional scaffolds favored the osteogenesis and vascularization in bone defect regions. To prove the hypothesis, the osteogenic and angiogenic activities of MYbHA/CS scaffolds were investigated by using rat bone marrow mesenchymal stem cells (rBMSCs) and rat cranial defects as models. Fortunately, both the magnetic fields and Yb³⁺ ions as-derived from MYbHA/CS scaffolds remarkably up-regulated the expression of osteogenic-related genes by activating BMP-2/Smad pathway, and simultaneously increased the expression of vascular endothelial growth factor. In vivo rat cranial defect models further revealed that the combination effects between magnetic SrFe₁₂O₁₉ nanoplates and Yb dopants remarkably stimulated the in-growth of blood vessels and new bones into three-dimensional channels in the nanohybrid scaffolds. Hence, the modification of SrFe₁₂O₁₉ nanoplates and Yb dopants in bone scaffolds is a novel and promising strategy to accelerate bone defect healing.

羟基磷灰石（HA）是一种传统的骨修复材料，但是其不良的成骨和血管生成能力阻碍了临界尺寸骨缺损愈合的临床应用。在这里，掺杂的羟基磷灰石（YbHA）纳米棒阵列原位沉积在磁性壳聚糖（CS）多孔支架中，从而产生磁性YbHA / CS（MYbHA / CS）纳米杂化支架。我们假设两种磁性SrFe ₁₂ O ₁₉功能支架中的纳米板和Yb掺杂剂有利于骨缺损区域的成骨和血管形成。为了证明这一假设，以大鼠骨髓间充质干细胞（rBMSCs）和大鼠颅骨缺损为模型，研究了MYbHA / CS支架的成骨和血管生成活性。幸运的是，MYbHA / CS支架产生的磁场和Yb ³⁺离子均通过激活BMP-2 / Smad途径显着上调了成骨相关基因的表达，并同时增加了血管内皮生长因子的表达。体内大鼠颅骨缺损模型进一步揭示了磁性SrFe ₁₂ O ₁₉之间的组合作用纳米板和Yb掺杂物显着刺激了血管和新骨的向内生长，进入了纳米混合支架的三维通道。因此，骨支架中SrFe ₁₂ O ₁₉纳米板和Yb掺杂物的修饰是一种新颖且有希望的策略，可加速骨缺损的愈合。