Mesenchymal stromal cells (MSCs) possess several fairly unique properties that, when combined, make them ideally suited for cellular-based immunotherapy and as vehicles for gene and drug delivery for a wide range of diseases and disorders. Key among these are: (1) their relative ease of isolation from a variety of tissues; (2) the ability to be expanded in culture without a loss of functionality, a property that varies to some degree with tissue source; (3) they are relatively immune-inert, perhaps obviating the need for precise donor/recipient matching; (4) they possess potent immunomodulatory functions that can be tailored by so-called licensing in vitro and in vivo; (5) the efficiency with which they can be modified with viral-based vectors; and (6) their almost uncanny ability to selectively home to damaged tissues, tumors, and metastases following systemic administration. In this review, we summarize the latest research in the immunological properties of MSCs, their use as immunomodulatory/anti-inflammatory agents, methods for licensing MSCs to customize their immunological profile, and their use as vehicles for transferring both therapeutic genes in genetic disease and drugs and genes designed to destroy tumor cells.

中文翻译：

---

治疗性间质基质细胞用于免疫治疗以及基因和药物传递。

间充质基质细胞（MSC）具有几个相当独特的特性，这些特性结合在一起后，使其非常适合基于细胞的免疫疗法，并且可以作为多种疾病和病症的基因和药物递送载体。其中的关键是：（1）它们相对容易与各种组织隔离；（2）在不丧失功能的情况下在培养中进行扩展的能力，这种特性会随组织来源的不同而有所不同；（3）它们是相对免疫惰性的，也许不需要精确的供体/受体匹配；（4）它们具有强大的免疫调节功能，可以通过所谓的体外和体内许可进行定制；（5）用基于病毒的载体修饰它们的效率；（6）他们几乎不可思议的能力，能够选择性地适应受损组织，肿瘤，和全身给药后的转移。在这篇综述中，我们总结了关于MSCs的免疫学特性，它们作为免疫调节/抗炎剂，许可MSCs定制其免疫学特征的方法以及它们作为在遗传疾病中转移治疗基因的载体的最新研究。旨在破坏肿瘤细胞的药物和基因。