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Is there a relationship between low-grade systemic inflammation and cognition in healthy people aged 60-75 years?
Behavioural Brain Research ( IF 2.7 ) Pub Date : 2020-01-22 , DOI: 10.1016/j.bbr.2020.112502
M T Fard 1 , L Cribb 2 , K Nolidin 1 , K Savage 1 , K Wesnes 3 , C Stough 1
Affiliation  

Although inflammation has been associated with cognitive impairment in dementia, less is known about its role in the cognition of middle to older aged healthy people. This study utilised baseline data from the Australian Research Council Longevity Intervention (ARCLI) trial to investigate the relationship between markers of systemic inflammation (TNF-α, IL-6, IL-1β, INF-γ, IL-2, IL-4, IL-10 and hsCRP) and cognitive function in 286 healthy volunteers aged 60-75 years. We assessed cognitive functioning across domains including attention, speed of memory, working memory and episodic memory using the Cognitive Drug Research test battery. Only IFN-γ was related to cognitive function, being associated with greater odds of having low continuity of attention (log2 IFN-γ OR, 1.46; 95 % CI, 1.18-1.85). The relationship between episodic memory, speed of memory and inflammation varied with BMI. In high BMI participants, increased inflammation was associated with worse cognitive function, while this association was reversed in those with low BMI. Outside of the influence of IFN-γ on attention, low-grade systemic inflammation was not robustly associated with cognitive function in this sample of middle to older aged healthy people. Further research is required to understand the role of BMI in the intersection of inflammation and cognitive function.

中文翻译:

在60-75岁的健康人群中,低度全身性炎症与认知之间是否存在关系?

尽管炎症与痴呆症的认知功能障碍有关,但人们对其炎症在中老年人健康认知中的作用知之甚少。这项研究利用了澳大利亚研究委员会长寿干预(ARCLI)试验的基线数据来研究系统性炎症标志物(TNF-α,IL-6,IL-1β,INF-γ,IL-2,IL-4, IL-10和hsCRP)和286名60-75岁的健康志愿者的认知功能。我们使用认知药物研究测试电池评估了跨领域的认知功能,包括注意力,记忆速度,工作记忆和情景记忆。只有IFN-γ与认知功能有关,与注意力连续性低的可能性更高(log2IFN-γOR,1.46; 95%CI,1.18-1.85)。情景记忆之间的关系,记忆和炎症的速度因BMI而异。在BMI较高的参与者中,炎症增加与认知功能下降有关,而在BMI较低的参与者中这种关系则相反。除了干扰素-γ对注意力的影响外,在这个中老年人健康样本中,低度全身性炎症与认知功能的关系不强。需要进一步的研究来了解BMI在炎症和认知功能的交集中的作用。在中老年人健康样本中,低度全身性炎症与认知功能没有强相关性。需要进一步的研究来了解BMI在炎症和认知功能的交集中的作用。在中老年人健康样本中,低度全身性炎症与认知功能没有强相关性。需要进一步的研究来了解BMI在炎症和认知功能的交集中的作用。
更新日期:2020-01-22
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