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Residential exposure to outdoor air pollution and adult lung function, with focus on small airway obstruction.
Environmental Research ( IF 8.3 ) Pub Date : 2020-01-21 , DOI: 10.1016/j.envres.2020.109161
Anaïs Havet 1 , Sébastien Hulo 1 , Damien Cuny 2 , Margaux Riant 3 , Florent Occelli 4 , Nathalie Cherot-Kornobis 1 , Jonathan Giovannelli 3 , Régis Matran 1 , Philippe Amouyel 3 , Jean-Louis Edmé 1 , Luc Dauchet 3
Affiliation  

Although a growing body of evidence suggests that chronic exposure to outdoor air pollution is linked to a decline in lung function, data on flow at low lung volumes that may be more specific of small airway obstruction are still scarce. We aimed to study the associations between residential exposure to air pollution and lung function, with specific focus on small airways obstruction. We assessed 2995 French participants (aged between 40 and 65) in the ELISABET cross-sectional survey. Residential exposures to nitrogen dioxide (NO2), particulate matter with a diameter <10 μm (PM10) and sulphur dioxide (SO2) were assessed. The spirometric parameters were forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and forced expiratory flow between 25% and 75% of FVC (FEF25-75) and at 75% of FVC (FEF75). Coefficients in linear regression models were expressed as the z-score [95% confidence interval] for an increment of 5 μg/m3 in NO2 and 2 μg/m3 in PM10 and SO2. NO2 was associated with significantly lower values of FEV1 (-0.10 [-0.15;-0.05]), FVC (-0.06 [-0.11;-0.02]), FEV1/FVC (-0.07 [-0.11;-0.03]), FEF25-75 (-0.09 [-0.14;-0.05]) and FEF75 (-0.08 [-0.12;-0.04]). PM10 was associated with significantly lower values of FEV1 (-0.10 [-0.15;-0.04]), FVC (-0.06 [-0.11;-0.01]), FEV1/FVC (-0.06 [‒0.11;-0.01]), FEF25-75 (-0.08 [-0.13;-0.03]) and FEF75 (-0.08 [-0.12;-0.04]). SO2 was associated with significantly lower values of FEV1 (-0.09 [-0.16;-0.02]), FEV1/FVC (-0.07 [-0.13;-0.01]), FEF25-75 (-0.09 [-0.15;-0.02]) and FEF75 (-0.08 [-0.14;-0.03]) but not FVC (-0.05 [-0.11; 0.009]). Even though spatial variations in pollutant levels were low, residential exposure to outdoor air pollution was associated with lower lung function, including lower FEF25-75 and FEF75 suggesting small airway obstruction.

中文翻译:

住宅暴露于室外空气污染和成年肺功能,重点是小气道阻塞。

尽管越来越多的证据表明,长期暴露于室外空气污染与肺功能下降有关,但仍缺乏关于低肺容量流量的数据,这种数据可能更具体地表现为小气道阻塞。我们旨在研究住宅暴露于空气污染与肺功能之间的关联,特别关注小气道阻塞。我们在ELISABET横断面调查中评估了2995名法国参与者(年龄在40至65岁之间)。评估了居民暴露于二氧化氮(NO2),直径小于10微米的颗粒物(PM10)和二氧化硫(SO2)的情况。肺活量测定参数为1秒内的强制呼气量(FEV1),强制肺活量(FVC)和FVC的25%至75%(FEF25-75)和FVC的75%(FEF75)之间的强制呼气流量。线性回归模型的系数表示为z分数[95%置信区间],其中NO2的增量为5μg/ m3,PM10和SO2的增量为2μg/ m3。NO2与FEV1(-0.10 [-0.15; -0.05]),FVC(-0.06 [-0.11; -0.02]),FEV1 / FVC(-0.07 [-0.11; -0.03])和FEF25值显着降低相关-75(-0.09 [-0.14; -0.05])和FEF75(-0.08 [-0.12; -0.04])。PM10与FEV1(-0.10 [-0.15; -0.04]),FVC(-0.06 [-0.11; -0.01]),FEV1 / FVC(-0.06 [‒0.11; -0.01]),FEF25的值显着较低相关-75(-0.08 [-0.13; -0.03])和FEF75(-0.08 [-0.12; -0.04])。SO2与FEV1(-0.09 [-0.16; -0.02]),FEV1 / FVC(-0.07 [-0.13; -0.01]),FEF25-75(-0.09 [-0.15; -0.02])的值明显较低相关和FEF75(-0.08 [-0.14; -0.03]),而不是FVC(-0.05 [-0.11; 0.009])。即使污染物水平的空间变化很小,
更新日期:2020-01-22
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