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Sprinkling the pixie dust: reflections on innovation and innovators in medicinal chemistry and drug discovery.
Drug Discovery Today ( IF 7.4 ) Pub Date : 2020-01-22 , DOI: 10.1016/j.drudis.2020.01.006
Simon J F Macdonald 1 , Richard J D Hatley 1
Affiliation  

Pharmaceutical innovation is in short supply. Many diagnoses have been made and remedies prescribed by those in the industry and those that comment on it. There is much less practical advice for the individual about becoming more innovative or managing innovation at the laboratory level, which is where new medicines are discovered. This article collates and reviews ideas selected from the literature and encountered over many years by medicinal chemists, team leaders and project leaders in a big pharma.

中文翻译:

撒上小精灵的灰尘:对药物化学和药物发现中的创新和创新者的思考。

医药创新供不应求。业内人士和评论人士已经做出了许多诊断和补救措施。对于个人而言,关于在实验室层面变得更具创新性或管理创新的实用建议要少得多,而实验室层面正是发现新药的地方。本文整理和回顾了大型制药公司的药物化学家、团队负责人和项目负责人多年来从文献中选择的想法。
更新日期:2020-04-20
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