Patients with inflammatory bowel diseases are exposed to an increased risk of intestinal cancer. Colorectal cancer associated with ulcerative colitis [UC] has been extensively studied. The main risk factors are longstanding evolution, lack of endoscopic and histological healing, extent of inflammation along the colon, and primary sclerosing cholangitis. In patients with UC, colorectal carcinogenesis follows an inflammation-dysplasia-cancer sequence. Epithelial dysplasia precedes colorectal cancer and both have specific molecular, histological, and endoscopic characteristics. Colorectal screening in patients with UC is based upon endoscopic diagnosis of dysplasia followed by endoscopic resection or colectomy.¹

中文翻译：

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克罗恩病相关小肠腺癌的分子和组织学解剖学研究进展。

肠炎性疾病患者患肠癌的风险增加。与溃疡性结肠炎[UC]相关的大肠癌已被广泛研究。主要危险因素是长期进化，缺乏内窥镜和组织学治愈，沿结肠的炎症程度以及原发性硬化性胆管炎。在UC患者中，结肠直肠癌的发生遵循炎症-不典型增生-癌症序列。上皮异型增生在大肠癌之前，并且都具有特定的分子，组织学和内窥镜特征。UC患者的结肠直肠癌筛查是基于内镜诊断为异型增生，然后进行内镜切除或结肠切除术。^1个