Naturally-acquired protection against upper respiratory symptoms involving group A Streptococcus in a longitudinal cohort study.,Clinical Infectious Diseases

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Naturally-acquired protection against upper respiratory symptoms involving group A Streptococcus in a longitudinal cohort study.
Clinical Infectious Diseases ( IF 11.8 ) Pub Date : 2020-01-19 , DOI: 10.1093/cid/ciaa044
Joseph A Lewnard _{1,

2,

3} , Lilith K Whittles _{4,

5,

6} , Anne-Marie Rick _{7,

8} , Judith M Martin _{7,

8}

Affiliation

Division of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Center for Computational Biology, College of Engineering, University of California, Berkeley, Berkeley, California, USA.
Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom.
Medical Research Council Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, United Kingdom.
National Institute for Health Research Health Protection Research Unit in Modelling Methodology, School of Public Health, Imperial College London, London, United Kingdom.
Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Department of Pediatrics, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Pharyngitis due to group A Streptococcus (GAS) represents a major cause of outpatient visits and antibiotic use in the United States. A leading vaccine candidate targets 30 of the > 200 emm types of GAS. We aimed to assess natural protection conferred by GAS against respiratory symptoms.

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