Impaired Cytokine Responses to Live Staphylococcus epidermidis in Preterm Infants Precede Gram-positive, Late-onset Sepsis,Clinical Infectious Diseases

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Impaired Cytokine Responses to Live Staphylococcus epidermidis in Preterm Infants Precede Gram-positive, Late-onset Sepsis
Clinical Infectious Diseases ( IF 11.8 ) Pub Date : 2020-01-21 , DOI: 10.1093/cid/ciaa063
Tobias Strunk _{1,

2,

3} , Julie Hibbert _{1,

3} , Dorota Doherty ₃ , Elizabeth Nathan ₃ , Karen Simmer _{1,

2,

3} , Peter Richmond _{3,

4} , Andrew Currie ₅ , David Burgner _{6,

7}

Affiliation

Late-onset sepsis (LOS) with Staphylococcus epidermidis is common in preterm infants, but the immunological mechanisms underlying heightened susceptibility are poorly understood. Our aim is to characterize the ontogeny of cytokine responses to live S. epidermidis in preterm infants with and without subsequent Gram-positive LOS.

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