The development of novel bioconjugation strategies is useful for various therapeutic and diagnostic applications. This work describes the synthesis and genetic encoding of an unnatural amino acid that serves as a functional handle for numerous bioconjugations. In particular it can be employed in bioorthogonal [2+2+2] cycloaddition reactions to either conjugate a small‐molecule probe/drug or to immobilize a protein on a surface. More information can be found in the communication by D. D. Young et al.

中文翻译：

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[2 + 2 + 2]环加成反应的生物缀合手柄的遗传编码。

新型生物缀合策略的发展对于各种治疗和诊断应用都是有用的。这项工作描述了一种非天然氨基酸的合成和遗传编码，该非天然氨基酸可作为多种生物偶联的功能性处理。特别是，它可用于生物正交[2 + 2 + 2]环加成反应中，以偶联小分子探针/药物或将蛋白质固定在表面上。在D. D. Young等人的来文中可以找到更多信息。