The construction of carboxylic acid compounds in a selective fashion from low value materials such as alkenes remains a long-standing challenge to synthetic chemists. In particular, β-addition to styrenes is underdeveloped. Herein we report a new electrosynthetic approach to the selective hydrocarboxylation of alkenes that overcomes the limitations of current transition metal and photochemical approaches. The reported method allows unprecedented direct access to carboxylic acids derived from β,β-trisubstituted alkenes, in a highly regioselective manner.

中文翻译：

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利用应用潜力：取代烯烃的选择性 β-羟基化

从烯烃等低价值材料中以选择性方式构建羧酸化合物仍然是合成化学家面临的长期挑战。特别是，β-加成到苯乙烯中是不发达的。在此，我们报告了一种新的电合成方法，用于烯烃的选择性加氢羧化，克服了当前过渡金属和光化学方法的局限性。所报道的方法允许以高度区域选择性的方式前所未有地直接获取衍生自 β,β-三取代烯烃的羧酸。