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Ultrasound-responsive Homopolymer Nanoparticles
Chinese Journal of Polymer Science ( IF 4.3 ) Pub Date : 2019-09-24 , DOI: 10.1007/s10118-020-2345-6
Bo Yang , Jian-Zhong Du

Abstract

Noninvasive ultrasound is a more effective strategy for on-demand drug delivery of polymeric nanoparticles than many other stimuli. However, the preparation of ultrasound-responsive homopolymer nanoparticles is still very challenging. In this study, we disclose the regulating factors of ultrasound responsiveness of homopolymer nanoparticles and the disaggregation behavior of homopolymer nanoparticle aggregates. Homopolymer nanoparticles such as vesicles and large compound micelles (LCMs) are self-assembled from poly(methoxyethyl methacrylate) (PMEMA) and poly(amic acid) (PAA), respectively. The ultrasound responsiveness of PAA vesicles at metastable state could be regulated by tuning the self-assembly temperature (Ts), and was optimized when Ts is around the glass transition temperature (Tg) of PAA. However, the PMEMA LCMs did not respond to ultrasound as they are at stable state. On the other hand, poly(2-(2-ethoxyethoxy)ethyl acrylate) (PEEA) could self-assemble into vesicle aggregates or complex micelle aggregates, which were dissociated upon sonication. Overall, the above findings provide us with a fresh insight for designing ultrasound-responsive polymeric nanoparticles.



中文翻译:

超声响应均聚物纳米粒子

摘要

与许多其他刺激相比,非侵入性超声是按需递送聚合物纳米颗粒的更有效策略。然而,超声响应性均聚物纳米粒子的制备仍然非常具有挑战性。在这项研究中,我们公开了均聚物纳米颗粒的超声响应能力的调节因素和均聚物纳米颗粒聚集体的分解行为。均聚物纳米粒子(例如囊泡和大化合物胶束(LCM))分别由聚甲基丙烯酸甲氧基乙酯(PMEMA)和聚酰胺酸(PAA)自组装而成。可以通过调节自组装温度(T s)调节亚稳状态下PAA囊泡的超声响应,并在T s时对其进行优化处于PAA的玻璃化转变温度(T g)附近。但是,PMEMA LCM处于稳定状态,因此对超声波没有反应。另一方面,聚(2-(2-乙氧基乙氧基)乙基丙烯酸酯)(PEEA)可以自组装为囊泡聚集体或复杂的胶束聚集体,它们在超声处理后会解离。总体而言,以上发现为我们提供了设计超声响应性聚合物纳米颗粒的新见识。

更新日期:2020-01-22
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