Abstract

Carbonate apatite (CO₃Ap) scaffolding has been widely used for bone repair and replacement due to its excellent osteoconductivity and resorbability in bone defects. However, the application of the porous scaffold has been limited by its brittleness. Here, CO₃Ap scaffolds coated with 1, 3 and 5 wt% of sodium alginate (SA) and bovine gelatine (BG) were fabricated to improve the mechanical properties of the porous scaffold. Limited studies have been done on a CO₃Ap scaffold coated with a natural polymer layer. Here, a CO₃Ap scaffold was fabricated through the phase transformation from β-tricalcium phosphate (β-TCP) to CO₃Ap using a hydrothermal method. Fourier-transform infrared (FTIR) analysis confirmed the presence of both SA and BG functional groups on the CO₃Ap scaffold. Five wt% of SA and BG improved the compressive strength of the uncoated CO₃Ap scaffold by 34% and 46%, respectively. The SA coating was found to enhance the compressive strength of the CO₃Ap scaffold compared to the BG coating due to its high viscosity. Furthermore, the compressive strength of the scaffold increased by 40% after undergoing a silanization process and being coated with SA. These results indicate that the use of a silane treatment improved the chemical bonding between the CO₃Ap scaffold and SA coating. This process increased the adhesion between the SA coating and the scaffold and improved the compressive strength.

中文翻译：

---

通过表面处理以及藻酸盐和明胶涂层增强碳酸盐磷灰石支架的性能

摘要

碳酸盐磷灰石（CO ₃ Ap）支架由于其出色的骨传导性和骨缺损的可吸收性而被广泛用于骨修复和置换。然而，多孔支架的应用受到其脆性的限制。此处，制造了涂覆有1、3和5 wt％的藻酸钠（SA）和牛明胶（BG）的CO ₃ Ap支架，以改善多孔支架的机械性能。对涂覆有天然聚合物层的CO ₃ Ap支架进行的研究有限。在此，通过从β-磷酸三钙（β-TCP）到CO ₃的相变制备了CO ₃ Ap支架Ap使用水热法。傅立叶变换红外（FTIR）分析证实了CO ₃ Ap支架上同时存在SA和BG官能团。5wt％的SA和BG分别使未涂覆的CO ₃ Ap支架的抗压强度分别提高了34％和46％。与BG涂层相比，发现SA涂层由于其高粘度而提高了CO ₃ Ap支架的抗压强度。此外，在进行硅烷化处理并涂覆有SA之后，支架的抗压强度提高了40％。这些结果表明使用硅烷处理改善了CO ₃之间的化学键合。Ap脚手架和SA涂层。该过程增加了SA涂层与支架之间的粘附力并提高了抗压强度。