An efficient, silver‐based catalytic system has been designed for the synthesis of biologically important 3‐aminoimidazo‐fused heterocycles via the Groebke‐Blackburn‐Bienayme reaction, in which AgOAc was used as a catalyst and ethylene glycol as a solvent from isocyanides, various aryl aldehydes and an 2‐amino heterocycle were also used. Good to excellent yields, high atomic economy and environmentally friendly conditions are the potential features of this one‐pot process.

中文翻译：

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通过乙酸银催化的Groebke-Blackburn-Bienayme反应与乙二醇作为可生物降解和可持续的溶剂合成咪唑并[1，2-a]吡啶

设计了一种有效的基于银的催化体系，用于通过Groebke-Blackburn-Bienayme反应合成生物学上重要的3-氨基咪唑并稠合的杂环，其中AgOAc被用作催化剂，乙二醇被异氰酸酯作为溶剂，各种还使用了芳基醛和2-氨基杂环。单锅法的潜在特征是高到优收率，高原子经济性和环境友好条件。