Plasmablasts play important roles in autoimmune diseases, including systemic lupus erythematosus (SLE ). Activation of mechanistic target of rapamycin complex 1 (mTORC 1) is regulated by amino acid levels. In patients with SLE , mTORC 1 is activated in B cells and modulates plasmablast differentiation. However, the detailed mechanisms of amino acid metabolism in plasmablast differentiation remain elusive. We undertook this study to evaluate the effects of methionine in human B cells.

中文翻译：

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蛋氨酸通过甲基转移酶EZH2通过BTB和CNC同源2的表观遗传调控使细胞分化为成浆细胞。

成纤维细胞在包括系统性红斑狼疮（SLE）在内的自身免疫疾病中起重要作用。雷帕霉素复合物1（mTORC 1）的机械靶标的激活受氨基酸水平的调节。在SLE患者中，mTORC 1在B细胞中被激活并调节成浆细胞分化。但是，在成浆细胞分化中氨基酸代谢的详细机制仍然难以捉摸。我们进行了这项研究，以评估蛋氨酸在人类B细胞中的作用。