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Incomplete Hydrolysis of Curcumin Conjugates by β-Glucuronidase: Detection of Complex Conjugates in Plasma.
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2020-01-29 , DOI: 10.1002/mnfr.201901037
Paula B Luis 1 , Andrew G Kunihiro 2 , Janet L Funk 2, 3 , Claus Schneider 1
Affiliation  

The diphenol curcumin from turmeric is rapidly metabolized into phase II conjugates following oral administration, resulting in negligible plasma concentration of the free compound, which is considered the bioactive form. Total plasma concentration of curcumin is often quantified after treatment with β‐glucuronidase to hydrolyze curcumin‐glucuronide, the most abundant conjugate in vivo. The efficiency of enzymatic hydrolysis has not been tested.

中文翻译:

β-葡糖醛酸糖苷酶对姜黄素结合物的不完全水解:血浆中复杂结合物的检测。

姜黄素的双酚姜黄素口服后迅速代谢成II期结合物,血浆中游离化合物的血浆浓度可忽略不计,这被认为是生物活性形式。姜黄素的总血浆浓度通常在用β-葡萄糖醛酸苷酶处理以水解姜黄素-葡萄糖醛酸苷(体内最丰富的结合物)后进行定量。酶水解的效率尚未经过测试。
更新日期:2020-01-29
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