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How the Mitoprotein-Induced Stress Response Safeguards the Cytosol: A Unified View.
Trends in Cell Biology ( IF 19.0 ) Pub Date : 2020-01-18 , DOI: 10.1016/j.tcb.2019.12.003
Felix Boos 1 , Johnathan Labbadia 2 , Johannes M Herrmann 1
Affiliation  

Mitochondrial and cytosolic proteostasis are of central relevance for cellular stress resistance and organismal health. Recently, a number of individual cellular programs were described that counter the fatal consequences of mitochondrial dysfunction. These programs remove arrested import intermediates from mitochondrial protein translocases, stabilize protein homeostasis within mitochondria, and, in particular, increase the levels and activity of chaperones and the proteasome system in the cytosol. Here, we describe the different responses to mitochondrial perturbation and propose to unify the seemingly distinct mitochondrial-cytosolic quality control mechanisms into a single network, the mitoprotein-induced stress response. This holistic view places mitochondrial biogenesis at a central position of the cellular proteostasis network, emphasizing the importance of mitochondrial protein import processes for development, reproduction, and ageing.

中文翻译:

线粒体蛋白诱导的应激反应如何保护细胞溶胶:统一的观点。

线粒体和胞质蛋白变性与细胞抗压力和机体健康具有重要关系。近来,描述了许多单独的细胞程序来对抗线粒体功能障碍的致命后果。这些程序从线粒体蛋白的转位酶中去除了​​被捕的进口中间体,稳定了线粒体内的蛋白稳态,特别是增加了细胞质中伴侣蛋白和蛋白酶体系统的水平和活性。在这里,我们描述了对线粒体微扰的不同反应,并提出将看似独特的线粒体-胞质控制机制统一到单个网络中,即线粒体蛋白诱导的应激反应。这种整体观点将线粒体的生物发生置于细胞蛋白稳态网络的中心位置,
更新日期:2020-01-21
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