BACKGROUND Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition characterized by chronic pelvic pain related to the bladder with no effective treatment options. OBJECTIVE To evaluate the efficacy and safety of transurethral resection (TUR) and transurethral coagulation (TUC) as treatments for Hunner lesion (HL) in IC/BPS. DESIGN, SETTING, AND PARTICIPANTS A single-center, prospective, randomized controlled trial involving 126 patients with HL in IC/BPS. INTERVENTION TUR or TUC. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS Primary outcome was recurrence-free time after surgery. Secondary outcomes included change of the number of frequency, nocturia, urgency episodes in voiding diaries, O'Leary-Sant Interstitial Cystitis Symptom Index (ICSI) and Interstitial Cystitis Problem Index (ICPI), pelvic pain and urgency/frequency (PUF) symptom scale, and visual analog scale (VAS) for pain and risk factors for recurrence. RESULTS AND LIMITATIONS There were no differences in the recurrence-free time between treatment groups, a difference of 12.2 mo (95% confidence interval [CI], 11.1-17.6) for TUR, and a difference of 11.5 mo (95% CI, 9.03-16.1; p=0.735) for TUC. No difference was found in decreased mean daytime frequency, nocturia, urgency episodes, ICSI, ICPI, PUF symptom scale, and VAS for pain between both groups over 12 mo. Regardless of treatment types, there were significant improvements in all symptom questionnaires and pain compared with baseline (all, p < 0.05). Treatment type (TUR or TUC), age, sex, previous history of hydrodistension, and number of HLs did not affect recurrence. Incidence of bladder injury was higher in the TUR group (7.9%) than in the TUC group (3.4%). CONCLUSIONS There was no difference in the recurrence-free time and effect on urinary symptoms, including pain between TUC and TUR, for HL. Taking into account procedure-related complications, the surgeon can choose the method with which he/she is most familiar and comfortable. PATIENT SUMMARY In patients with bladder pain syndrome with Hunner lesions, both endoscopic resection and coagulation of the lesions are effective treatments.

中文翻译：

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间质性膀胱炎/膀胱疼痛综合征患者中经尿道凝结术和经尿道切除术治疗匈奴病灶的疗效比较：一项前瞻性随机对照试验。

背景技术间质性膀胱炎/膀胱疼痛综合征（IC / BPS）是一种慢性病，其特征是与膀胱有关的慢性盆腔痛，没有有效的治疗选择。目的评估经尿道切除术（TUR）和经尿道凝结术（TUC）作为IC / BPS中Hunner病灶（HL）的治疗方法的有效性和安全性。设计，地点和参与者一项单中心，前瞻性，随机对照试验，涉及126名IC / BPS HL患者。干预TUR或TUC。结果测量和统计分析主要结果是术后无复发时间。次要结果包括频率变化，夜尿症，排尿日记中的尿急发作，O'Leary-Sant间质性膀胱炎症状指数（ICSI）和间质性膀胱炎问题指数（ICPI），骨盆疼痛和尿急/频率（PUF）症状量表，以及视觉模拟量表（VAS）用于疼痛和复发危险因素。结果与局限性治疗组之间的无复发时间无差异，TUR差异为12.2 mo（95％置信区间[CI]，11.1-17.6），差异为11.5 mo（95％CI，9.03） -16.1; p = 0.735）。两组均超过12个月时，两组的平均日间频率降低，夜尿症，尿急发作，ICSI，ICCPI，PUF症状量表和VAS对疼痛的影响无差异。不论治疗类型如何，所有症状问卷和疼痛均较基线水平有显着改善（所有，p <0.05）。治疗类型（TUR或TUC），年龄，性别，既往的水肿史以及HL的数量均不影响复发。TUR组（7.9％）的膀胱损伤发生率高于TUC组（3.4％）。结论HL患者的无复发时间和对尿液症状（包括TUC和TUR之间的疼痛）的影响没有差异。考虑到手术相关的并发症，外科医生可以选择最熟悉和舒适的方法。病人总结对于患有Hunner病灶的膀胱疼痛综合征患者，内镜下切除术和病灶凝固术都是有效的治疗方法。