Allopurinol (ALO) is a radical scavenging clinical drug, a drug in the treatment of gout, an inhibitor of xanthine oxidase and an effective agent for anti-cancer purposes. The xanthine oxidase is thus essential, and the amount of ALO needs to be controlled more strictly. In this study, a new electrochemical sensor based on magnetite graphene oxide/ordered mesoporous carbon (Fe3O4@GO/OMC) hybrid was prepared and characterized. The results showed sphere shape Fe3O4 nanoparticles with a diameter in the range 17-22 nm on composite. Modification of carbon paste electrode (CPE) with Fe3O4@GO/OMC (Fe3O4@GO/OMC-CPE) allowed the ultrasensitive and selective detection of ALO at oxidation potential of 1.05 V with linear range of 0.05-7 μmol L-1, limit of detection of 47 nmol L-1 and sensitivity of 708 μA mmol-1 L. Also, the results demonstrate that charge transfer at the interface of Fe3O4@GO/OMC hybrid can provide a synergistic effect in comparison with Fe3O4@GO and OMC. The unique surface chemistry of Fe3O4@GO/OMC interface allows π-π stacking and electrostatic interactions with ALO. The advantages are the possibility to regenerate the surface of the sensor, its rapid and easy of production, as well as its applicability for detection of ALO in Tablets and human serum samples, making Fe3O4@GO/OMC-CPE promising interface for bio-electrochemical applications.

中文翻译：

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基于磁铁矿氧化石墨烯/有序介孔碳杂化体的电化学传感器，用于检测临床样品中的别嘌呤醇。

别嘌醇（ALO）是一种清除自由基的临床药物，是一种治疗痛风的药物，是黄嘌呤氧化酶的抑制剂和抗癌的有效药物。因此，黄嘌呤氧化酶是必不可少的，需要更严格地控​​制ALO的量。在这项研究中，基于磁铁矿氧化石墨烯/有序介孔碳（Fe3O4 @ GO / OMC）杂化的新型电化学传感器被制备和表征。结果显示在复合材料上直径为17-22 nm的球形Fe3O4纳米颗粒。用Fe3O4 @ GO / OMC（Fe3O4 @ GO / OMC-CPE）修饰碳糊电极（CPE）可以在1.05 V氧化电势下线性检测0.05-7μmolL-1（极限）的超灵敏和选择性检测ALO检测47 nmol L-1和灵敏度为708μAmmol-1L。结果表明，与Fe3O4 @ GO和OMC相比，Fe3O4 @ GO / OMC杂化物界面上的电荷转移可以提供协同效应。Fe3O4 @ GO / OMC界面的独特表面化学性质允许π-π堆积以及与ALO的静电相互作用。优点是可以再生传感器的表面，快速且易于生产以及适用于检测片剂和人血清样品中的ALO，从而使Fe3O4 @ GO / OMC-CPE成为生物电化学的有希望的界面应用程序。