BACKGROUND Accurately documenting pediatric atopic dermatitis (AD) severity is important, but research tools, such as Eczema Area and Severity Index (EASI), are too time consuming for clinical settings. Product of the Physician Global Assessment and affected percentage of body surface area (PGA×BSA) is a new, rapid measure of psoriasis severity. OBJECTIVE To evaluate an Investigator Global Assessment and body surface area product (IGA×BSA) as an easy-to-use severity measure for pediatric AD. METHODS Patient-reported and objective disease severity measures were collected from 195 caretaker/child dyads (child age range, 5-17 years) with almost clear (Validated Investigator Global Assessment for AD [vIGA] of 1) to severe (vIGA of 4) AD. Data were assessed with Spearman coefficients and plots. Severity strata were proposed by using an anchoring approach based on the EASI. RESULTS IGA×BSA correlates better with the EASI than IGA alone (r = 0.924 vs r = 0.757, P < .001). Bland-Altman plot indicates high and consistent agreement between IGA×BSA and the EASI. Suggested severity strata for IGA×BSA are 0-30, mild; 30.1-130, moderate; and 130.1-400, severe (κ = 0.760). LIMITATIONS The patient cohort was predominantly from the midwestern United States. CONCLUSIONS IGA×BSA (using the vIGA) is a simple measure that correlates well with the EASI in patients with mild to severe pediatric AD. Future work is needed to affirm reliability across IGA scales and responsiveness to change.

中文翻译：

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研究者全球评估和体表面积 (IGAxBSA) 的产品：湿疹面积和严重程度指数的实用替代方案，用于评估儿童特应性皮炎的严重程度。

背景准确记录儿童特应性皮炎 (AD) 的严重程度很重要，但湿疹面积和严重程度指数 (EASI) 等研究工具对于临床环境而言过于耗时。医师整体评估和受影响的体表面积百分比 (PGA×BSA) 的产品是一种新的快速衡量银屑病严重程度的方法。目的 评估研究者整体评估和体表面积产品 (IGA×BSA) 作为一种易于使用的儿科 AD 严重程度测量方法。方法 从 195 名看护者/儿童二人组（儿童年龄范围，5-17 岁）中收集患者报告的客观疾病严重程度测量结果，从几乎明确（经验证的研究者 AD [vIGA] 总体评估为 1）到严重（vIGA 为 4）广告。使用 Spearman 系数和图评估数据。严重程度分层是通过使用基于 EASI 的锚定方法提出的。结果 IGA×BSA 与 EASI 的相关性比单独的 IGA 更好（r = 0.924 vs r = 0.757，P < .001）。Bland-Altman 图表明 IGA×BSA 与 EASI 之间高度一致。IGA×BSA 的建议严重程度等级为 0-30，轻度；30.1-130，中等；130.1-400，严重（κ = 0.760）。局限性 患者群体主要来自美国中西部。结论 IGA×BSA（使用 vIGA）是一种简单的测量方法，与轻度至重度儿科 AD 患者的 EASI 具有良好的相关性。未来需要开展工作来确认 IGA 规模的可靠性和对变化的响应能力。