Background

Patients with chronic inflammatory skin disease (CISD) have potential risk factors for herpes zoster (HZ). However, little is known about HZ risk in CISD.

Objective

To determine whether CISD is associated with HZ.

Methods

Data were analyzed from the 2002 to 2012 Nationwide Inpatient Sample, a representative cohort of US hospitalizations (N = 68,088,221 children and adults).

Results

In multivariable logistic regression models including age, sex, race/ethnicity, insurance, household income, and long-term systemic corticosteroid use, hospitalization for HZ was associated with atopic dermatitis (adjusted odds ratio [95% confidence interval], 1.38 [1.14-1.68]), psoriasis (4.78 [2.83-8.08]), pemphigus (1.77 [1.01-3.12]), bullous pemphigoid (1.77 [1.01-3.12]), mycosis fungoides (3.79 [2.55-5.65]), dermatomyositis (7.31 [5.27-10.12]), systemic sclerosis (1.92 [1.47-2.53]), cutaneous lupus erythematosus (1.94 [1.10-3.44]), vitiligo (2.00 [1.04-3.85]), and sarcoidosis (1.52 [1.22-1.90]). Only lichen planus (crude odds ratio [95% confidence interval], 3.01 [1.36-6.67]), Sézary syndrome (12.14 [5.20-28.31]), morphea (2.74 [1.36-5.51]), and pyoderma gangrenosum (2.44 [1.16-5.13]) showed increased odds in bivariable models. Sensitivity analyses among those younger than 60 and younger than 50 years showed similar results. Predictors of HZ in CISD included female sex, fewer chronic conditions, and long-term systemic corticosteroid use.

Limitations

Cross-sectional study.

Conclusions

Many CISDs are associated with increased hospitalization for HZ, even below the ages recommended for HZ vaccination. Additional studies are needed to establish CISD-specific vaccination guidelines.

中文翻译：

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美国住院患者带状疱疹与慢性炎症性皮肤病的关联

背景

慢性炎症性皮肤病 (CISD) 患者具有潜在的带状疱疹 (HZ) 危险因素。然而，关于 CISD 中的 HZ 风险知之甚少。

客观的

确定 CISD 是否与 HZ 相关联。

方法

分析了 2002 年至 2012 年全国住院患者样本的数据，该样本是美国住院患者的代表性队列（N = 68,088,221 名儿童和成人）。

结果

在包括年龄、性别、种族/民族、保险、家庭收入和长期全身性皮质类固醇使用在内的多变量逻辑回归模型中，HZ 住院与特应性皮炎相关（调整后的比值比 [95% 置信区间]，1.38 [1.14- 1.68])、银屑病 (4.78 [2.83-8.08])、天疱疮 (1.77 [1.01-3.12])、大疱性类天疱疮 (1.77 [1.01-3.12])、蕈样真菌病 (3.79 [2.55-5.65])、皮肌炎 (7.31 [ 5.27-10.12]）、系统性硬化症（1.92 [1.47-2.53]）、皮肤红斑狼疮（1.94 [1.10-3.44]）、白斑病（2.00 [1.04-3.85]）和结节病（1.52 [1.22-1.90]）。只有扁平苔藓（粗比值比 [95% 置信区间]，3.01 [1.36-6.67]）、Sézary 综合征（12.14 [5.20-28.31]）、硬斑病（2.74 [1.36-5.51]）和坏疽性脓皮病（2.44 [1.16] -5.13]) 在双变量模型中表现出增加的几率。60 岁以下和 50 岁以下人群的敏感性分析显示出相似的结果。CISD 中 HZ 的预测因素包括女性、较少的慢性病和长期全身性皮质类固醇使用。

限制

横断面研究。

结论

许多 CISD 与带状疱疹住院率增加有关，甚至低于建议接种带状疱疹疫苗的年龄。需要更多的研究来建立 CISD 特定的疫苗接种指南。