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Geometric dependence of 3D collective cancer invasion
Biophysical Journal ( IF 3.4 ) Pub Date : 2020-03-01 , DOI: 10.1016/j.bpj.2020.01.008 Jihan Kim 1 , Yu Zheng 2 , Amani A Alobaidi 1 , Hanqing Nan 3 , Jianxiang Tian 4 , Yang Jiao 5 , Bo Sun 1
Biophysical Journal ( IF 3.4 ) Pub Date : 2020-03-01 , DOI: 10.1016/j.bpj.2020.01.008 Jihan Kim 1 , Yu Zheng 2 , Amani A Alobaidi 1 , Hanqing Nan 3 , Jianxiang Tian 4 , Yang Jiao 5 , Bo Sun 1
Affiliation
Metastasis of mesenchymal tumor cells is traditionally considered as a single-cell process. Here, we report an emergent collective phenomenon in which the dissemination rate of mesenchymal breast cancer cells from three-dimensional tumors depends on the tumor geometry. Combining experimental measurements and computational modeling, we demonstrate that the collective dynamics is coordinated by the mechanical feedback between individual cells and their surrounding extracellular matrix (ECM). We find the tissue-like fibrous ECM supports long-range physical interactions between cells, which turn geometric cues into regulated cell dissemination dynamics. Our results suggest that migrating cells in three-dimensional ECM represent a distinct class of an active particle system in which the collective dynamics is governed by the remodeling of the environment rather than direct particle-particle interactions.
中文翻译:
3D 集体癌症侵袭的几何依赖性
间充质肿瘤细胞的转移传统上被认为是一个单细胞过程。在这里,我们报告了一种新兴的集体现象,其中来自三维肿瘤的间充质乳腺癌细胞的传播率取决于肿瘤的几何形状。结合实验测量和计算模型,我们证明集体动力学是由单个细胞与其周围细胞外基质 (ECM) 之间的机械反馈协调的。我们发现组织状纤维 ECM 支持细胞之间的长程物理相互作用,这将几何线索转化为受调节的细胞传播动力学。
更新日期:2020-03-01
中文翻译:
3D 集体癌症侵袭的几何依赖性
间充质肿瘤细胞的转移传统上被认为是一个单细胞过程。在这里,我们报告了一种新兴的集体现象,其中来自三维肿瘤的间充质乳腺癌细胞的传播率取决于肿瘤的几何形状。结合实验测量和计算模型,我们证明集体动力学是由单个细胞与其周围细胞外基质 (ECM) 之间的机械反馈协调的。我们发现组织状纤维 ECM 支持细胞之间的长程物理相互作用,这将几何线索转化为受调节的细胞传播动力学。